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PDE4D Antibody (MA5-38426) in WB
Western Blot analysis of PDE4D using PDE4D Monoclonal Antibody (Product # MA5-38426) at 1:1,000. Positive WB detected in: THP-1 whole cell lysate. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 92, 77, 69, 67, 58, 85, 24, 60, 78, 77, 85, 25 kDa. Observed band size: 92 kDa
Product Details
MA5-38426
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4D4
Immunogen
A synthesized peptide derived from human PDE4D
Conjugate
Form
Liquid
Concentration
0.85 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 150mM NaCl
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2898340
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; DKFZp686M11213; DPDE3; FLJ97311; HGNC:8783; HS PDE4DN2; PDE43; PDE4D3; PDE4D7; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136
Gene Aliases: ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1
UniProt ID: (Human) Q08499
Entrez Gene ID: (Human) 5144
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
aging
regulation of receptor activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
neutrophil chemotaxis
regulation of cAMP metabolic process
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
negative regulation of heart contraction
T cell receptor signaling pathway
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of relaxation of cardiac muscle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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