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Product Details
PA5-50565
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human Platelet-derived growth factor alpha polypeptide
Conjugate
Form
Liquid
Concentration
2.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2636018
Product Specific Information
The antibody detects endogenous levels of total PDGFA protein.
Target Information
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PDGF A-chain; PDGF subunit A; PDGF-1; platelet derived growth factor, alpha; Platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A
Gene Aliases: PDGF-A; PDGF1; PDGFA; PDGFACP; Rpa1
UniProt ID: (Human) P04085, (Rat) P28576, (Mouse) P20033
Entrez Gene ID: (Human) 5154, (Rat) 25266, (Mouse) 18590
Ras guanyl-nucleotide exchange factor activity
platelet-derived growth factor receptor binding
protein binding
collagen binding
growth factor activity
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
platelet-derived growth factor binding
growth factor
MAPK cascade
angiogenesis
response to hypoxia
cell activation
hair follicle development
positive regulation of mesenchymal cell proliferation
platelet degranulation
transforming growth factor beta receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
response to wounding
organ morphogenesis
response to inorganic substance
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of smooth muscle cell migration
cell projection assembly
actin cytoskeleton organization
extracellular matrix organization
positive regulation of cell migration
positive regulation of protein autophosphorylation
response to estradiol
response to retinoic acid
regulation of actin cytoskeleton organization
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
wound healing
response to drug
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of GTPase activity
skin development
positive regulation of DNA replication
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
lung alveolus development
inner ear development
regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
positive regulation of cell division
positive regulation of protein kinase B signaling
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
positive regulation of ERK1 and ERK2 cascade
regulation of glomerular mesangial cell proliferation
embryonic lung development
regulation of DNA biosynthetic process
blood coagulation
response to organic substance
digestive tract development
multicellular organism development
bone development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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