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Product Details
H00005154-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PDGFA (NP_002598.4, 1 a.a. approximately 211 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRTLACLLLL GCGYLAHVLA EEAEIPREVI ERLARSQIHS IRDLQRLLEI DSVGSEDSLD TSLRAHGVHA TKHVPEKRPL PIRRKRSIEE AVPAVCKTRT VIYEIPRSQV DPTSANFLIW PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA TTSLNPDYRE EDTGRPRESG KKRKRKRLKP T
Target Information
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PDGF A-chain; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A
Gene Aliases: PDGF-A; PDGF1; PDGFA
UniProt ID: (Human) P04085
Entrez Gene ID: (Human) 5154
Ras guanyl-nucleotide exchange factor activity
platelet-derived growth factor receptor binding
protein binding
collagen binding
growth factor activity
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
platelet-derived growth factor binding
growth factor
MAPK cascade
angiogenesis
response to hypoxia
cell activation
hair follicle development
positive regulation of mesenchymal cell proliferation
platelet degranulation
transforming growth factor beta receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
response to wounding
organ morphogenesis
response to inorganic substance
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of smooth muscle cell migration
cell projection assembly
actin cytoskeleton organization
extracellular matrix organization
positive regulation of cell migration
positive regulation of protein autophosphorylation
response to estradiol
response to retinoic acid
regulation of actin cytoskeleton organization
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
wound healing
response to drug
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of GTPase activity
skin development
positive regulation of DNA replication
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
lung alveolus development
inner ear development
regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
positive regulation of cell division
positive regulation of protein kinase B signaling
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
positive regulation of ERK1 and ERK2 cascade
regulation of glomerular mesangial cell proliferation
embryonic lung development
regulation of DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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