Proteintech

PDGFRB Polyclonal Antibody

PDGFRB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDGFRB Antibody (13449-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human placenta tissue slide using (Product # 13449-1-AP) PDGFRB antibody at dilution of 1:4,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

PDGFRB Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

13449-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:4,000

Immunocytochemistry (ICC/IF)

View 9 publications 9 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDGFRB Fusion Protein Ag4285 (755-1106 aa encoded by BC032224)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LDMKGDVKY ADIESSNYMA PYDNYVPSAP ERTCRATLIN ESPVLSYMDL VGFSYQVANG MEFLASKNCV HRDLAARNVL ICEGKLVKIC DFGLARDIMR DSNYISKGST FLPLKWMAPE SIFNSLYTTL SDVWSFGILL WEIFTLGGTP YPELPMNEQF YNAIKRGYRM AQPAHASDEI YEIMQKCWEE KFEIRPPFSQ LVLLLERLLG EGYKKKYQQV DEEFLRSDHP AILRSQARLP GFHGLRSPLD TSSVLYTAVQ PNEGDNDYII PLPDPKPEVA DEGPLEGSPS LASSTLNEVN TSSTISCDSP LEPQDEPEPE PQLELQVEPE PELEQLPDSG CPAPRAEAED SFL (755-1106 aa encoded by B C032224)

Target Information

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Discovery of grey matter lesion-related immune genes for diagnostic prediction in multiple sclerosis.

PeerJ

Zhao P,Liu X,Wang Y,Zhang X,Wang H,Du X,Du Z,Yang L,Hou J

Wed May 03 00:00:00 EDT 2023

Discovery of grey matter lesion-related immune genes for diagnostic prediction in multiple sclerosis.

PeerJ

Zhao P,Liu X,Wang Y,Zhang X,Wang H,Du X,Du Z,Yang L,Hou J

Wed May 03 00:00:00 EDT 2023

Supramolecular Hydrogel Microspheres of Platelet-Derived Growth Factor Mimetic Peptide Promote Recovery from Spinal Cord Injury.

ACS nano

Wu W,Jia S,Xu H,Gao Z,Wang Z,Lu B,Ai Y,Liu Y,Liu R,Yang T,Luo R,Hu C,Kong L,Huang D,Yan L,Yang Z,Zhu L,Hao D

Tue Feb 28 00:00:00 EST 2023

Supramolecular Hydrogel Microspheres of Platelet-Derived Growth Factor Mimetic Peptide Promote Recovery from Spinal Cord Injury.

ACS nano

Wu W,Jia S,Xu H,Gao Z,Wang Z,Lu B,Ai Y,Liu Y,Liu R,Yang T,Luo R,Hu C,Kong L,Huang D,Yan L,Yang Z,Zhu L,Hao D

Tue Feb 28 00:00:00 EST 2023

Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting.

JCI insight

Gimple RC,Zhang G,Wang S,Huang T,Lee J,Taori S,Lv D,Dixit D,Halbert ME,Morton AR,Kidwell RL,Dong Z,Prager BC,Kim LJ,Qiu Z,Zhao L,Xie Q,Wu Q,Agnihotri S,Rich JN

Wed Mar 22 00:00:00 EDT 2023

Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting.

JCI insight

Gimple RC,Zhang G,Wang S,Huang T,Lee J,Taori S,Lv D,Dixit D,Halbert ME,Morton AR,Kidwell RL,Dong Z,Prager BC,Kim LJ,Qiu Z,Zhao L,Xie Q,Wu Q,Agnihotri S,Rich JN

Wed Mar 22 00:00:00 EDT 2023

Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.

Journal of ethnopharmacology

Liu L,Liang D,Zheng Q,Zhao M,Lv R,Tang J,Chen N

Wed Mar 01 00:00:00 EST 2023

Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.

Journal of ethnopharmacology

Liu L,Liang D,Zheng Q,Zhao M,Lv R,Tang J,Chen N

Wed Mar 01 00:00:00 EST 2023

Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.

Journal of ethnopharmacology

Liu L,Liang D,Zheng Q,Zhao M,Lv R,Tang J,Chen N

Wed Mar 01 00:00:00 EST 2023

Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.

Journal of ethnopharmacology

Liu L,Liang D,Zheng Q,Zhao M,Lv R,Tang J,Chen N

Wed Mar 01 00:00:00 EST 2023

Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma.

Laboratory investigation; a journal of technical methods and pathology

Safaric Tepes P,Segovia D,Jevtic S,Ramirez D,Lyons SK,Sordella R

Thu Sep 01 00:00:00 EDT 2022

Astragalus propinquus schischkin and Salvia miltiorrhiza bunge promote angiogenesis to treat myocardial ischemia via Ang-1/Tie-2/FAK pathway.

Frontiers in pharmacology

Zhang MX,Huang XY,Song Y,Xu WL,Li YL,Li C

Thu Feb 02 00:00:00 EST 2023

Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling.

iScience

Wang R,Wang Y,Liao G,Chen B,Panettieri RA,Penn RB,Tang DD

Fri Feb 18 00:00:00 EST 2022

Artemisinin suppressed tumour growth and induced vascular normalisation in oral squamous cell carcinoma via inhibition of macrophage migration inhibitory factor.

Oral diseases

Yu XH,Wu JB,Fan HY,Dai L,Xian HC,Chen BJ,Liao P,Huang MC,Pang X,Zhang M,Liang XH,Tang YL

Wed Nov 02 00:00:00 EDT 2022

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N⁶-methyladenosine.

Developmental cell

Lv D,Gimple RC,Zhong C,Wu Q,Yang K,Prager BC,Godugu B,Qiu Z,Zhao L,Zhang G,Dixit D,Lee D,Shen JZ,Li X,Xie Q,Wang X,Agnihotri S,Rich JN

Mon Jun 20 00:00:00 EDT 2022

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N⁶-methyladenosine.

Developmental cell

Lv D,Gimple RC,Zhong C,Wu Q,Yang K,Prager BC,Godugu B,Qiu Z,Zhao L,Zhang G,Dixit D,Lee D,Shen JZ,Li X,Xie Q,Wang X,Agnihotri S,Rich JN

Mon Jun 20 00:00:00 EDT 2022

Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation.

British journal of cancer

Yao X,He Z,Qin C,Zhang P,Sui C,Deng X,Fang Y,Li G,Shi J

Thu Sep 01 00:00:00 EDT 2022

Expanding tubular microvessels on stiff substrates with endothelial cells and pericytes from the same adult tissue.

Journal of tissue engineering

Song X,Yu Y,Leng Y,Ma L,Mu J,Wang Z,Xu Y,Zhu H,Qiu X,Li P,Li J,Wang D

Fri Sep 30 00:00:00 EDT 2022

Halofuginone inhibits tumor migration and invasion by affecting cancer-associated fibroblasts in oral squamous cell carcinoma.

Frontiers in pharmacology

Wang D,Tian M,Fu Y,Sun Y,Ding L,Zhang X,Jing Y,Sun G,Ni Y,Song Y

Wed Dec 21 00:00:00 EST 2022

Halofuginone inhibits tumor migration and invasion by affecting cancer-associated fibroblasts in oral squamous cell carcinoma.

Frontiers in pharmacology

Wang D,Tian M,Fu Y,Sun Y,Ding L,Zhang X,Jing Y,Sun G,Ni Y,Song Y

Wed Dec 21 00:00:00 EST 2022

PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.

Journal of materials chemistry. B

Zhang Z,Li Z,Wang Y,Wang Q,Yao M,Zhao L,Shi J,Guan F,Ma S

Sat Aug 21 00:00:00 EDT 2021

Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis.

Frontiers in oncology

Geng B,Zhu Y,Yuan Y,Bai J,Dou Z,Sui A,Luo W

Fri Mar 18 00:00:00 EDT 2022

TMEM119 facilitates ovarian cancer cell proliferation, invasion, and migration via the PDGFRB/PI3K/AKT signaling pathway.

Journal of translational medicine

Sun T,Bi F,Liu Z,Yang Q

Wed Mar 17 00:00:00 EDT 2021

Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer.

Frontiers in oncology

Tang H,Zheng J,Bai X,Yue KL,Liang JH,Li DY,Wang LP,Wang JL,Guo Q

Fri Dec 18 00:00:00 EST 2020

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Stem cells international

Sun B,Luo X,Yang C,Liu P,Yang Y,Dong X,Yang Z,Xu J,Zhang Y,Li L

Thu May 13 00:00:00 EDT 2021

Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia.

Aging

Yang E,Cai Y,Yao X,Liu J,Wang Q,Jin W,Wu Q,Fan W,Qiu L,Kang C,Wu J

Mon Nov 18 00:00:00 EST 2019

Blocking CXCR3 with AMG487 ameliorates the blood-retinal barrier disruption in diabetic mice through anti-oxidative.

Life sciences

Wang H,Li J,Zhong P,Wang S,Zhang L,Yang R,Wu D,Chen M,Ji A,Li Y,Wang J

Mon Jul 01 00:00:00 EDT 2019

Blocking CXCR3 with AMG487 ameliorates the blood-retinal barrier disruption in diabetic mice through anti-oxidative.

Life sciences

Wang H,Li J,Zhong P,Wang S,Zhang L,Yang R,Wu D,Chen M,Ji A,Li Y,Wang J

Mon Jul 01 00:00:00 EDT 2019

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue.

Journal of molecular cell biology

Tang Y,Qian SW,Wu MY,Wang J,Lu P,Li X,Huang HY,Guo L,Sun X,Xu CJ,Tang QQ

Mon Aug 01 00:00:00 EDT 2016

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue.

Journal of molecular cell biology

Tang Y,Qian SW,Wu MY,Wang J,Lu P,Li X,Huang HY,Guo L,Sun X,Xu CJ,Tang QQ

Mon Aug 01 00:00:00 EDT 2016

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue.

Journal of molecular cell biology

Tang Y,Qian SW,Wu MY,Wang J,Lu P,Li X,Huang HY,Guo L,Sun X,Xu CJ,Tang QQ

Mon Aug 01 00:00:00 EDT 2016

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue.

Journal of molecular cell biology

Tang Y,Qian SW,Wu MY,Wang J,Lu P,Li X,Huang HY,Guo L,Sun X,Xu CJ,Tang QQ

Mon Aug 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide

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Gene Aliases: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT

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UniProt ID: (Human) P09619, (Rat) Q05030, (Mouse) P05622

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Entrez Gene ID: (Human) 5159, (Rat) 24629, (Mouse) 18596

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Function(s)

protein tyrosine kinase activity platelet activating factor receptor activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity Ras guanyl-nucleotide exchange factor activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding protein kinase binding vascular endothelial growth factor binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity platelet-derived growth factor binding protein kinase activity signal transducer activity kinase activity nucleotide binding transmembrane receptor protein tyrosine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDGFRB Polyclonal Antibody

PDGFRB Antibody (13449-1-AP) in IHC (P)

Product Details

13449-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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