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Product Details
MA5-14851
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
R.140.4
Immunogen
GST fusion protein containing a carboxyl-terminal fragment of human PDGF receptor ß
Conjugate
Form
Liquid
Concentration
7 µg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_10981698
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other PDGF receptor family members.
Target Information
PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide
Gene Aliases: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT
UniProt ID: (Human) P09619, (Rat) Q05030, (Mouse) P05622
Entrez Gene ID: (Human) 5159, (Rat) 24629, (Mouse) 18596
protein tyrosine kinase activity
platelet activating factor receptor activity
platelet-derived growth factor-activated receptor activity
platelet-derived growth factor beta-receptor activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
platelet-derived growth factor receptor binding
protein binding
ATP binding
protein kinase binding
vascular endothelial growth factor binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
platelet-derived growth factor binding
protein kinase activity
signal transducer activity
kinase activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
MAPK cascade
glycosaminoglycan biosynthetic process
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
response to toxic substance
positive regulation of phospholipase C activity
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
response to estradiol
positive regulation of phosphoprotein phosphatase activity
response to retinoic acid
regulation of actin cytoskeleton organization
positive regulation of collagen biosynthetic process
response to fluid shear stress
cell migration involved in vasculogenesis
metanephric mesenchymal cell migration
platelet-derived growth factor receptor-beta signaling pathway
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
aorta morphogenesis
cellular response to platelet-derived growth factor stimulus
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
wound healing
response to hydrogen peroxide
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of mitotic nuclear division
phosphatidylinositol metabolic process
protein autophosphorylation
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
inner ear development
positive regulation of chemotaxis
cardiac myofibril assembly
response to hyperoxia
cell chemotaxis
cell migration involved in coronary angiogenesis
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
smooth muscle cell chemotaxis
metanephric mesenchyme development
metanephric glomerular mesangial cell proliferation involved in metanephros development
metanephric glomerular capillary formation
metanephric comma-shaped body morphogenesis
metanephric S-shaped body morphogenesis
positive regulation of calcium ion import
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
in utero embryonic development
kidney development
tissue homeostasis
nitrogen compound metabolic process
response to organic cyclic compound
phosphorylation
hemopoiesis
adrenal gland development
response to lipid
intracellular signal transduction
skeletal system morphogenesis
smooth muscle tissue development
regulation of peptidyl-tyrosine phosphorylation
metanephric glomerulus morphogenesis
protein phosphorylation
chemotaxis
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
cardiac vascular smooth muscle cell differentiation
Performance Guarantee
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