Proteintech

PERK/EIF2AK3 Polyclonal Antibody

PERK/EIF2AK3 Antibody in Immunocytochemistry (ICC/IF)

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PERK/EIF2AK3 Antibody (24390-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 24390-1-AP (PERK antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PERK/EIF2AK3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PERK/EIF2AK3 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

24390-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 63 publications 63 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PERK/EIF2AK3 Fusion Protein Ag18254 (767-1116 aa encoded by BC126354)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TDCDVEDGT MDGNDEGHSF ELCPSEASPY VRSRERTSSS IVFEDSGCDN ASSKEEPKTN RLHIGNHCAN KLTAFKPTSS KSSSEATLSI SPPRPTTLSL DLTKNTTEKL QPSSPKVYLY IQMQLCRKEN LKDWMNGRCT IEERERSVCL HIFLQIAEAV EFLHSKGLMH RDLKPSNIFF TMDDVVKVGD FGLVTAMDQD EEEQTVLTPM PAYARHTGQV GTKLYMSPEQ IHGNSYSHKV DIFSLGLILF ELLYPFSTQM ERVRTLTDVR NLKFPPLFTQ KYPCEYVMVQ DMLSPSPMER PEAINIIENA VFEDLDFPGK TVLRQRSRSL SSSGTKHSRQ SNNSHSPLPS N (767-1116 aa encoded by BC126354)

Target Information

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.

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Experimental and therapeutic medicine

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Mon May 01 00:00:00 EDT 2017

Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.

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Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

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Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.

Chemical research in toxicology

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Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.

Chemical research in toxicology

Xu D,Su C,Song X,Shi Q,Fu J,Hu L,Xia X,Song E,Song Y

Mon Jun 15 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase

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Gene Aliases: EIF2AK3; PEK; PERK; WRS

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UniProt ID: (Human) Q9NZJ5

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Entrez Gene ID: (Human) 9451

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Function(s)

protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein binding ATP binding enzyme binding protein phosphatase binding identical protein binding protein homodimerization activity Hsp90 protein binding non-receptor serine/threonine protein kinase

Process(es)

skeletal system development ossification angiogenesis chondrocyte development protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process ER overload response endoplasmic reticulum organization positive regulation of vascular endothelial growth factor production positive regulation of gene expression regulation of translational initiation by eIF2 alpha phosphorylation negative regulation of translation peptidyl-serine phosphorylation calcium-mediated signaling insulin secretion bone mineralization endoplasmic reticulum unfolded protein response endocrine pancreas development negative regulation of myelination negative regulation of translational initiation in response to stress cellular response to amino acid starvation response to endoplasmic reticulum stress eiF2alpha phosphorylation in response to endoplasmic reticulum stress PERK-mediated unfolded protein response cellular response to glucose starvation positive regulation of transcription from RNA polymerase I promoter protein autophosphorylation insulin-like growth factor receptor signaling pathway protein homooligomerization regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation cellular response to cold positive regulation of protein localization to nucleus regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway response to manganese-induced endoplasmic reticulum stress

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PERK/EIF2AK3 Polyclonal Antibody

PERK/EIF2AK3 Antibody (24390-1-AP) in ICC/IF

Product Details

24390-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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