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PEX5 Antibody (PA5-29047) in IHC (P)
PEX5 Polyclonal Antibody detects PEX5 protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. PEX5 Polyclonal Antibody (Product # PA5-29047) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29047
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 31 and 311 of Human PEX5
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546523
Product Specific Information
Recommended positive controls: A431.
Predicted reactivity: Mouse (91%), Bovine (97%), Guinea pig (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: peroxin 5; Peroxin-5; peroxisomal biogenesis factor 5; Peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 (SKL type) receptor; Peroxisomal targeting signal 1 receptor; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; Peroxisome receptor 1; PTS1 BP; PTS1 receptor; PTS1-BP; PXR1P
Gene Aliases: AW212715; ESTM1; PBD2A; PBD2B; PEX5; PTS1-BP; PTS1R; PXR1; RCDP5; X83306
UniProt ID: (Human) P50542, (Mouse) O09012
Entrez Gene ID: (Human) 5830, (Mouse) 19305
protein import into peroxisome matrix
protein import into peroxisome matrix, docking
protein import into peroxisome membrane
negative regulation of protein homotetramerization
very long-chain fatty acid metabolic process
neuron migration
protein targeting to peroxisome
fatty acid beta-oxidation
transport
mitochondrion organization
mitochondrial membrane organization
endoplasmic reticulum organization
peroxisome organization
isoprenoid biosynthetic process
protein transport
protein import into peroxisome matrix, translocation
cerebral cortex cell migration
cerebral cortex neuron differentiation
positive regulation of multicellular organism growth
cellular lipid metabolic process
cell development
neuromuscular process
protein tetramerization
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