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FIGURE: 1 / 3
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
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Protein Aliases: Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic leucine-rich nuclear phosphoprotein 32 family member B; Acidic leucine-rich nuclear phosphoprotein 32 family member E; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein 32 family, member A; acidic nuclear phosphoprotein 32 family, member B; Acidic nuclear phosphoprotein pp32; Acidic protein rich in leucines; cerebellar leucine rich acidic nuclear protein; Cerebellar postnatal development protein 1; hepatopoietin Cn; inhibitor-1 of protein phosphatase-2A; LANP; LANP-L; LANP-like protein; Leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; leucine-rich acidic nuclear protein like; Mapmodulin; PHAPI; PHAPI2; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; pp32; proliferation related acidic leucine rich protein PAL31; Proliferation-related acidic leucine-rich protein PAL31; Putative HLA-DR-associated protein I; Putative HLA-DR-associated protein I-2; putative human HLA class II associated protein I; Silver-stainable protein SSP29; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Gene Aliases: 2410015B15Rik; 2810018A15Rik; AI047746; AI326868; Anp32; ANP32A; ANP32B; ANP32E; APRIL; C15orf1; CPD1; HPPCn; I1PP2A; LANP; LANP-L; LANPL; MAPM; mLANP-L; PAL31; PHAP1; PHAPI; PHAPI2; PHAPI2a; PP32; SSP29; W91701
UniProt ID: (Human) P39687, (Human) Q92688, (Human) Q9BTT0, (Rat) P49911, (Mouse) O35381, (Mouse) Q9EST5, (Rat) Q9EST6, (Mouse) P97822, (Rat) Q5XIE0
Entrez Gene ID: (Human) 8125, (Human) 10541, (Human) 81611, (Rat) 25379, (Mouse) 11737, (Mouse) 67628, (Rat) 170724, (Mouse) 66471, (Rat) 361999
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