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Product Details
PA1-28342
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids near the amino terminus of human PHAP (accession no. P39687).
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1959536
Product Specific Information
Recommended positive controls: Raji cell lysate.
Target Information
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic (leucine-rich) nuclear phosphoprotein 32 family, member D; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic leucine-rich nuclear phosphoprotein 32 family member B; Acidic leucine-rich nuclear phosphoprotein 32 family member E; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein 32 family, member A; acidic nuclear phosphoprotein 32 family, member B; Acidic nuclear phosphoprotein pp32; Acidic protein rich in leucines; cerebellar leucine rich acidic nuclear protein; Cerebellar postnatal development protein 1; hepatopoietin Cn; inhibitor-1 of protein phosphatase-2A; LANP; LANP-L; LANP-like protein; Leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; leucine-rich acidic nuclear protein like; Mapmodulin; PHAPI; PHAPI2; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; pp32; proliferation related acidic leucine rich protein PAL31; Proliferation-related acidic leucine-rich protein PAL31; Putative HLA-DR-associated protein I; Putative HLA-DR-associated protein I-2; putative human HLA class II associated protein I; Silver-stainable protein SSP29; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Gene Aliases: 2410015B15Rik; 2810018A15Rik; AI047746; AI326868; Anp32; ANP32A; ANP32B; ANP32D; ANP32E; APRIL; C15orf1; CPD1; HPPCn; I1PP2A; LANP; LANP-L; LANPL; MAPM; mLANP-L; PAL31; PHAP1; PHAPI; PHAPI2; PHAPI2a; PP32; SSP29; W91701
nucleocytoplasmic transport
transcription, DNA-templated
regulation of transcription, DNA-templated
intracellular signal transduction
regulation of mRNA stability
vasculature development
nucleosome assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
ventricular system development
negative regulation of cell differentiation
positive regulation of protein export from nucleus
inner ear development
palate development
covalent chromatin modification
negative regulation of catalytic activity
histone exchange
G1/S transition of mitotic cell cycle
positive regulation of cell proliferation
positive regulation of G1/S transition of mitotic cell cycle
chromatin modification
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