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PIK3CA Antibody (PA5-18610) in IHC (P)
Immunohistochemistry (PFA fixed) analysis of PIK3CA using PIK3CA Polyclonal Antibody (Product # PA5-18610) (2.5 µg/mL) in staining of paraffin embedded Human Brain (Cerebellar Cortex). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Details
PA5-18610
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (HQWLKDKNKGEIYD) corresponding to the internal amino acids of PIK3CA
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_10987426
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Preliminary analysis showed no signal in Western Blot.
Target Information
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; pi3kca; PIK3R1; pk3ca; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA
Gene Aliases: CLOVE; CWS5; MCAP; MCM; MCMTC; p110-alpha; PI3K; PI3K-alpha; PIK3CA
UniProt ID: (Human) P42336
Entrez Gene ID: (Human) 5290
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
1-phosphatidylinositol-3-kinase activity
protein kinase activator activity
phosphatidylinositol 3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
insulin receptor substrate binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
kinase
angiogenesis
liver development
vasculature development
glucose metabolic process
protein phosphorylation
phosphatidylinositol biosynthetic process
epidermal growth factor receptor signaling pathway
regulation of gene expression
regulation of phosphatidylinositol 3-kinase signaling
platelet activation
T cell costimulation
activation of protein kinase activity
positive regulation of peptidyl-serine phosphorylation
phosphatidylinositol-3-phosphate biosynthetic process
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
regulation of multicellular organism growth
regulation of cellular respiration
protein kinase B signaling
negative regulation of neuron apoptotic process
endothelial cell migration
hypomethylation of CpG island
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
leukocyte migration
cardiac muscle contraction
adipose tissue development
cellular response to glucose stimulus
energy homeostasis
mitophagy in response to mitochondrial depolarization
negative regulation of fibroblast apoptotic process
regulation of genetic imprinting
negative regulation of anoikis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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