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Invitrogen
PIK3R4 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
PA5-28917
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 895 and 1258 of Human p150(PIK3R4)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546393
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (98%), Rat (98%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-Kinase p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3-kinase VPS15
Gene Aliases: 2210010O15Rik; C730038E05Rik; C85833; D9Ertd418e; p150; PIK3R4; VPS15
UniProt ID: (Human) Q99570, (Mouse) Q8VD65
Entrez Gene ID: (Human) 30849, (Mouse) 75669
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase modulator
protein-binding activity modulator
protein phosphorylation
protein targeting to vacuole
phosphatidylinositol biosynthetic process
macroautophagy
pexophagy
regulation of cytokinesis
receptor catabolic process
toll-like receptor 9 signaling pathway
phosphatidylinositol-3-phosphate biosynthetic process
cellular response to glucose starvation
positive regulation of phosphatidylinositol 3-kinase activity
late endosome to vacuole transport
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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