Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: ALSSSTSPRAP PSHRPLKSPQ NETLYSVLK
Highest antigen sequence identity to the following orthologs - mouse 50%, rat 57%.
SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILR beta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR alpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cell surface receptor FDF03; Inhibitory receptor PILR-alpha; paired immunoglobin-like type 2 receptor alpha; Paired immunoglobulin-like type 2 receptor alpha
Gene Aliases: FDF03; PILRA
UniProt ID: (Human) Q9UKJ1
Entrez Gene ID: (Human) 29992
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