Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MATDDKTSP TLDSANDLPR SPTSPSHLTH FKPLTPDQDE PPFKSAYSSF VNLFRFNKER AEGGQGEQQP LSGSWTSPQL PSRTQSVRSP TPYKKQLNEE LQRRSSALGD LRACTYCRKI ALSYAHSTDS NSIGEDLNAL SDSACSVSVL DPSEPRTPVG SRKASRNIFL EDDLAWQSLI HPDSSNTPLS TRLVSVQEDA GKSPARNRSA SITNLSLDRS GSPMVPSYET SVSPQANRTY VRTETTEDER KILLDSVQLK DLWKKICHHS SGMEFQDHRY WLRTHPNCIV GKELVNWLIR NGHIATRAQA IAIGQAMVDG RWLDCVSHHD QLFRDEYALY RPLQSTEFSE TPSPDSDSVN SVEGHSEPSW FKDIKFDDSD TEQIAEEGDD NLANSASPSK RTSVSSFQST VDSDSAASIS LNVELDNVNF HIKKPSKYPH VPPHPADQKG RR (1-451 aa encoded by BC032389)
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; epididymis luminal protein 37; FYVE finger-containing phosphoinositide kinase; p235; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; PtdIns(4)P-5-kinase; Serine-protein kinase PIKFYVE; type III PIP kinase; zinc finger, FYVE domain containing 29
Gene Aliases: 5230400C17Rik; CFD; FAB1; HEL37; KIAA0981; p235; PIKFYVE; PIP5K; PIP5K3; Pipk5k3; PipkIII; ZFYVE29
UniProt ID: (Human) Q9Y2I7, (Mouse) Q9Z1T6
Entrez Gene ID: (Human) 200576, (Rat) 316457, (Mouse) 18711
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