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The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease.
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Protein Aliases: hPreP; Metalloprotease 1; metalloprotease 1 (pitrilysin family); nuclear transplantation upregulated protein 1; pitrilysin metalloprotease 1; Pitrilysin metalloproteinase 1; PreP peptidasome; Presequence protease, mitochondrial
Gene Aliases: 2310012C15Rik; AA410010; KIAA1104; mKIAA1104; MP-1; MP1; Ntup1; PITRM1; PREP
UniProt ID: (Human) Q5JRX3, (Mouse) Q8K411
Entrez Gene ID: (Human) 10531, (Mouse) 69617
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