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Product Details
PA5-34710
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 197 and 606 of PKC epsilon (Uniprot ID#Q02156)
Conjugate
Form
Liquid
Concentration
0.92 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2552062
Product Specific Information
Recommended positive controls: A431.
Predicted reactivity: Mouse (96%), Rat (97%), Rabbit (98%), Rhesus Monkey (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The PKC family of serine/threonine kinases, including PRKCE (PKC epsilon), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC125656; MGC125657; nPKC-epsilon; PKC e; Protein kinase C epsilon type; protein kinase C, epsilon
Gene Aliases: nPKC-epsilon; PKCE; PRKCE
UniProt ID: (Human) Q02156
Entrez Gene ID: (Human) 5581
actin monomer binding
protein serine/threonine kinase activity
protein kinase C activity
calcium-independent protein kinase C activity
signal transducer activity
protein binding
ATP binding
enzyme activator activity
enzyme binding
receptor activator activity
ethanol binding
metal ion binding
14-3-3 protein binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
macrophage activation involved in immune response
protein phosphorylation
apoptotic process
cell cycle
cell adhesion
signal transduction
activation of phospholipase C activity
positive regulation of epithelial cell migration
positive regulation of fibroblast migration
positive regulation of cell-substrate adhesion
peptidyl-serine phosphorylation
platelet activation
positive regulation of actin filament polymerization
negative regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of insulin secretion
positive regulation of synaptic transmission, GABAergic
positive regulation of cytokinesis
intracellular signal transduction
locomotory exploration behavior
TRAM-dependent toll-like receptor 4 signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to morphine
positive regulation of MAPK cascade
regulation of peptidyl-tyrosine phosphorylation
positive regulation of lipid catabolic process
release of sequestered calcium ion into cytosol
regulation of release of sequestered calcium ion into cytosol
cell division
regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of mucus secretion
cellular response to ethanol
cellular response to prostaglandin E stimulus
cellular response to hypoxia
positive regulation of wound healing
positive regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity
positive regulation of cellular glucuronidation
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