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Product Details
PA5-53333
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PLCE1. Recombinant protein control fragment (Product #RP-90791).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2645632
Product Specific Information
Immunogen sequence: MGISPLGNQS VIIETGRAHP DSRRAVFHFH YEVDRRMSDT FCTLSENLIL DDCGNCVPLP GGEEKQKKNY VAYTCKLMEL AKNCDNKNEQ LQCDHCDTLN DKYFCFEGSC EKVDMVYSGD SFCRKDFTDS QAAKT
Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 57%.
Target Information
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; Pancreas-enriched phospholipase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1; phospholipase C, epsilon 1; Phospholipase C-epsilon-1; PLC-epsilon-1
Gene Aliases: KIAA1516; NPHS3; PLCE; PLCE1; PPLC
UniProt ID: (Human) Q9P212
Entrez Gene ID: (Human) 51196
activation of MAPK activity
regulation of cell growth
phospholipid metabolic process
diacylglycerol biosynthetic process
regulation of smooth muscle contraction
cytoskeleton organization
epidermal growth factor receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
Ras protein signal transduction
heart development
regulation of G-protein coupled receptor protein signaling pathway
cell proliferation
lipid catabolic process
calcium-mediated signaling
glomerulus development
positive regulation of GTPase activity
inositol phosphate metabolic process
regulation of protein kinase activity
regulation of Ras protein signal transduction
inositol phosphate-mediated signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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