Proteintech

PLDN Polyclonal Antibody

PLDN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

PLDN Antibody (10891-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 10891-2-AP ( PLDN antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PLDN Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10891-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PLDN Fusion Protein Ag1337 (1-172 aa encoded by BC004819)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSVPGPSSP DGALTRPPYC LEAGEPTPGL SDTSPDEGLI EDLTIEDKAV EQLAEGLLSH YLPDLQRSKQ ALQELTQNQV VLLDTLEQEI SKFKECHSML DINALFAEAK HYHAKLVNIR KEMLMLHEKT SKLKKRALKL QQKRQKEELE REQQREKEFE REKQLTARPA KRM (1-172 aa encoded by BC004819)

Target Information

The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue. The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1⁺ cells via ciliary TGF-β signaling.

eLife

Xiao H,Zhang T,Li C,Cao Y,Wang L,Chen H,Li S,Guan C,Hu J,Chen D,Chen C,Lu H

Wed Apr 27 00:00:00 EDT 2022

Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.

eLife

Wells KM,He K,Pandey A,Cabello A,Zhang D,Yang J,Gomez G,Liu Y,Chang H,Li X,Zhang H,Feng X,da Costa LF,Metz R,Johnson CD,Martin CL,Skrobarczyk J,Berghman LR,Patrick KL,Leibowitz J,Ficht A,Sze SH,Song J,Qian X,Qin QM,Ficht TA,de Figueiredo P

Thu May 19 00:00:00 EDT 2022

Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice.

Cells

Borlepawar A,Schmiedel N,Eden M,Christen L,Rosskopf A,Frank D,Lüllmann-Rauch R,Frey N,Rangrez AY

Sat Oct 31 00:00:00 EDT 2020

BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor.

eLife

Zhang C,Hao C,Shui G,Li W

Thu Nov 12 00:00:00 EST 2020

Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.

American journal of respiratory cell and molecular biology

Kook S,Qi A,Wang P,Meng S,Gulleman P,Young LR,Guttentag SH

Tue May 01 00:00:00 EDT 2018

Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.

American journal of respiratory cell and molecular biology

Kook S,Qi A,Wang P,Meng S,Gulleman P,Young LR,Guttentag SH

Tue May 01 00:00:00 EDT 2018

Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.

Journal of neurochemistry

Ito A,Fukaya M,Saegusa S,Kobayashi E,Sugawara T,Hara Y,Yamauchi J,Okamoto H,Sakagami H

Mon Oct 01 00:00:00 EDT 2018

Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.

Journal of neurochemistry

Ito A,Fukaya M,Saegusa S,Kobayashi E,Sugawara T,Hara Y,Yamauchi J,Okamoto H,Sakagami H

Mon Oct 01 00:00:00 EDT 2018

Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.

Journal of neurochemistry

Ito A,Fukaya M,Saegusa S,Kobayashi E,Sugawara T,Hara Y,Yamauchi J,Okamoto H,Sakagami H

Mon Oct 01 00:00:00 EDT 2018

Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.

Journal of neurochemistry

Ito A,Fukaya M,Saegusa S,Kobayashi E,Sugawara T,Hara Y,Yamauchi J,Okamoto H,Sakagami H

Mon Oct 01 00:00:00 EDT 2018

Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.

Journal of neurochemistry

Ito A,Fukaya M,Saegusa S,Kobayashi E,Sugawara T,Hara Y,Yamauchi J,Okamoto H,Sakagami H

Mon Oct 01 00:00:00 EDT 2018

Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.

Journal of neurochemistry

Ito A,Fukaya M,Saegusa S,Kobayashi E,Sugawara T,Hara Y,Yamauchi J,Okamoto H,Sakagami H

Mon Oct 01 00:00:00 EDT 2018

Dynamic of contribution of UBPy-sorted cargo to acrosome biogenesis: effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant.

Cell and tissue research

Gioria M,Pasini ME,Berruti G

Tue Aug 01 00:00:00 EDT 2017

Dynamic of contribution of UBPy-sorted cargo to acrosome biogenesis: effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant.

Cell and tissue research

Gioria M,Pasini ME,Berruti G

Tue Aug 01 00:00:00 EDT 2017

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.

Current biology : CB

Delevoye C,Heiligenstein X,Ripoll L,Gilles-Marsens F,Dennis MK,Linares RA,Derman L,Gokhale A,Morel E,Faundez V,Marks MS,Raposo G

Mon Jan 11 00:00:00 EST 2016

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.

Current biology : CB

Delevoye C,Heiligenstein X,Ripoll L,Gilles-Marsens F,Dennis MK,Linares RA,Derman L,Gokhale A,Morel E,Faundez V,Marks MS,Raposo G

Mon Jan 11 00:00:00 EST 2016

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.

Current biology : CB

Delevoye C,Heiligenstein X,Ripoll L,Gilles-Marsens F,Dennis MK,Linares RA,Derman L,Gokhale A,Morel E,Faundez V,Marks MS,Raposo G

Mon Jan 11 00:00:00 EST 2016

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.

Current biology : CB

Delevoye C,Heiligenstein X,Ripoll L,Gilles-Marsens F,Dennis MK,Linares RA,Derman L,Gokhale A,Morel E,Faundez V,Marks MS,Raposo G

Mon Jan 11 00:00:00 EST 2016

The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking.

Neuroscience

Yang W,Zhu C,Shen Y,Xu Q

Sat Oct 01 00:00:00 EDT 2016

The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking.

Neuroscience

Yang W,Zhu C,Shen Y,Xu Q

Sat Oct 01 00:00:00 EDT 2016

BORC, a multisubunit complex that regulates lysosome positioning.

Developmental cell

Pu J,Schindler C,Jia R,Jarnik M,Backlund P,Bonifacino JS

Mon Apr 20 00:00:00 EDT 2015

BORC, a multisubunit complex that regulates lysosome positioning.

Developmental cell

Pu J,Schindler C,Jia R,Jarnik M,Backlund P,Bonifacino JS

Mon Apr 20 00:00:00 EDT 2015

The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Mullin AP,Zlatic SA,Easley CA,Merritt ME,Raj N,Larimore J,Gordon DE,Peden AA,Sanyal S,Faundez V

Wed May 13 00:00:00 EDT 2015

The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Mullin AP,Zlatic SA,Easley CA,Merritt ME,Raj N,Larimore J,Gordon DE,Peden AA,Sanyal S,Faundez V

Wed May 13 00:00:00 EDT 2015

Dysbindin-associated proteome in the p2 synaptosome fraction of mouse brain.

Journal of proteome research

Han MH,Hu Z,Chen CY,Chen Y,Gucek M,Li Z,Markey SP

Fri Nov 07 00:00:00 EST 2014

Dysbindin-associated proteome in the p2 synaptosome fraction of mouse brain.

Journal of proteome research

Han MH,Hu Z,Chen CY,Chen Y,Gucek M,Li Z,Markey SP

Fri Nov 07 00:00:00 EST 2014

Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.

Molecular biology of the cell

Zlatic SA,Grossniklaus EJ,Ryder PV,Salazar G,Mattheyses AL,Peden AA,Faundez V

Thu Aug 01 00:00:00 EDT 2013

Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.

Molecular biology of the cell

Zlatic SA,Grossniklaus EJ,Ryder PV,Salazar G,Mattheyses AL,Peden AA,Faundez V

Thu Aug 01 00:00:00 EDT 2013

The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.

Molecular biology of the cell

Ryder PV,Vistein R,Gokhale A,Seaman MN,Puthenveedu MA,Faundez V

Mon Jul 01 00:00:00 EDT 2013

The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.

Molecular biology of the cell

Ryder PV,Vistein R,Gokhale A,Seaman MN,Puthenveedu MA,Faundez V

Mon Jul 01 00:00:00 EDT 2013

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Larimore J,Werner E,So L,Moreno-De-Luca A,Lese-Martin C,Lupashin VV,Smith Y,Faundez V

Wed Mar 14 00:00:00 EDT 2012

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Larimore J,Werner E,So L,Moreno-De-Luca A,Lese-Martin C,Lupashin VV,Smith Y,Faundez V

Wed Mar 14 00:00:00 EDT 2012

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Larimore J,Werner E,So L,Moreno-De-Luca A,Lese-Martin C,Lupashin VV,Smith Y,Faundez V

Wed Mar 14 00:00:00 EDT 2012

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Larimore J,Werner E,So L,Moreno-De-Luca A,Lese-Martin C,Lupashin VV,Smith Y,Faundez V

Wed Mar 14 00:00:00 EDT 2012

Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Newell-Litwa K,Chintala S,Jenkins S,Pare JF,McGaha L,Smith Y,Faundez V

Wed Jan 20 00:00:00 EST 2010

Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Newell-Litwa K,Chintala S,Jenkins S,Pare JF,McGaha L,Smith Y,Faundez V

Wed Jan 20 00:00:00 EST 2010

Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.

Molecular biology of the cell

Newell-Litwa K,Salazar G,Smith Y,Faundez V

Sun Mar 01 00:00:00 EST 2009

Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.

Molecular biology of the cell

Newell-Litwa K,Salazar G,Smith Y,Faundez V

Sun Mar 01 00:00:00 EST 2009

Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.

The Journal of biological chemistry

Salazar G,Zlatic S,Craige B,Peden AA,Pohl J,Faundez V

Fri Jan 16 00:00:00 EST 2009

Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.

The Journal of biological chemistry

Salazar G,Zlatic S,Craige B,Peden AA,Pohl J,Faundez V

Fri Jan 16 00:00:00 EST 2009

Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.

The Journal of biological chemistry

Salazar G,Zlatic S,Craige B,Peden AA,Pohl J,Faundez V

Fri Jan 16 00:00:00 EST 2009

Bioinformatics

Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 5, pallidin; biogenesis of lysosomal organelles complex-1, subunit 6, pallidin; Biogenesis of lysosome-related organelles complex 1 subunit 6; biogenesis of organelles complex-1, subunit 6, pallidin; BLOC-1 subunit 6; Pallid protein; Pallid protein homolog; Pallidin; pallidin homolog; syntaxin 13 binding protein 1; Syntaxin 13-interacting protein; syntaxin 13-interacting protein pallid

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Gene Aliases: BLOC-1; BLOC1S6; BLOS6; HPS9; P2; PA; PALLID; PLDN; Stx13bp1

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UniProt ID: (Human) Q9UL45, (Rat) Q4V8A6, (Mouse) Q9R0C0

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Entrez Gene ID: (Human) 26258, (Rat) 317630, (Mouse) 18457

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Function(s)

protein binding syntaxin binding identical protein binding protein homodimerization activity actin filament binding

Process(es)

blood coagulation anterograde axonal transport melanocyte differentiation neuron projection development melanosome transport positive regulation of natural killer cell activation secretion of lysosomal enzymes endosome to melanosome transport pigmentation anterograde synaptic vesicle transport positive regulation of pigment cell differentiation membrane fusion synaptic vesicle docking melanosome organization vesicle docking involved in exocytosis vesicle fusion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PLDN Polyclonal Antibody

PLDN Antibody (10891-2-AP) in IHC (P)

Product Details

10891-2-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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