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FIGURE: 1 / 1
PLOD2 Antibody (CL647-21214) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.2 µg CoraLite® Plus 647 Anti-Human PLOD2-Specific (CL647-21214) (red), or 0.2 µg Isotype Control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL647-21214
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion Protein
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PYMANVYLIK GKTLRSEMNE RNYFVRDKLD PDMALCRNAR EMTLQREKDS PTPETFQMLS PPKGVFMYIS NRHEFGRLLS TA
Target Information
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LH2; lysine hydroxylase 2; lysyl hydroxlase 2; Lysyl hydroxylase 2; Procollagen-lysine 2-oxoglutarate 5-dioxygenase (Lysine hydroxylase) 2; procollagen-lysine 5-dioxygenase; Procollagen-lysine, 2-oxoglutarate 5-dioxygenase (Lysine hydroxylase) 2; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; telopeptide lysyl hydroxylase
Gene Aliases: BRKS2; D530025C14Rik; LH2; Plod-2; PLOD2; TLH
UniProt ID: (Human) O00469, (Mouse) Q9R0B9
Entrez Gene ID: (Human) 5352, (Rat) 300901, (Mouse) 26432
iron ion binding
procollagen-lysine 5-dioxygenase activity
L-ascorbic acid binding
molecular_function
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
metal ion binding
dioxygenase activity
protein modifying enzyme
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