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Invitrogen
PLXNB2 Polyclonal Antibody
FIGURE: 1 / 7
PLXNB2 Antibody (PA5-47880) in WB
Western blot analysis from lysates of M1 mouse myeloid leukemia cell line, mouse lung tissue, and mouse ovary tissue. PVDF membrane was probed with 0.5 µg/mL of Sheep Anti-mouse Plexin B2 Antigen Affinity-purified Polyclonal Antibody (Product # PA5-47880) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody. Specific bands were detected for Plexin B2 at approximately 240 and 150 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-47880
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse,
Zebrafish
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant mouse Plexin B2 Leu20-Trp1029
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2610560
Product Specific Information
In direct ELISAs, approximately 9% cross-reactivity with recombinant human Plexin B2 is observed, and less than 1% cross-reactivity with recombinant mouse Plexin B3 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Plexin-B2 is a member of the Semaphorin receptor family. The semaphorin family consists of membrane and secreted proteins involved in attraction and repulsion of neuronal guidance cues. Plexin-B1 is a transmembrane protein that can be cleaved converting the single chain precursor into a heterodimeric receptor. It has been shown to bind Sema4D/CD100 and is involved in axon development in mouse embryos. Sema4D also plays a role in the immune system interacting with CD72. Plexin-B2's possible role in the immune system has not been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: differentially expressed in brain tumors; MM1KIAA0315dJ402G11.3; Plexin-B2
Gene Aliases: Debt; plexin-B2; Plxnb2
UniProt ID: (Mouse) B2RXS4
Entrez Gene ID: (Mouse) 140570
neural tube closure
regulation of protein phosphorylation
signal transduction
multicellular organism development
neuroblast proliferation
brain development
regulation of cell shape
regulation of GTPase activity
positive regulation of axonogenesis
semaphorin-plexin signaling pathway
regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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