Invitrogen

PMCA ATPase Polyclonal Antibody

View all (4) PMCA ATPase antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-114932

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ATP2B4(Accession P23634), corresponding to amino acid residues K302-L352.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2899568

Product Specific Information

Antibody detects endogenous levels of total Calcium Pump PMCA4 ATPase.

Target Information

The calcium pump of the plasma membrane (PMCA ATPase) pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the sarcoplasmic and endoplasmic reticulum calcium (SERCA) ATPase and the sodium/potassium pump. Studies indicate that there are four known isoforms of the PMCA ATPase which are encoded by a multigene family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase, Ca++ transporting, plasma membrane 1; ATPase, Ca++ transporting, plasma membrane 2; ATPase, Ca++ transporting, plasma membrane 3; ATPase, Ca++ transporting, plasma membrane 4; cilia and flagella associated protein 39; deaf waddler; Matrix-remodeling-associated protein 1; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 1; Plasma membrane calcium pump isoform 2; Plasma membrane calcium pump isoform 3; Plasma membrane calcium pump isoform 4; Plasma membrane calcium-transporting ATPase 1; Plasma membrane calcium-transporting ATPase 2; Plasma membrane calcium-transporting ATPase 3; Plasma membrane calcium-transporting ATPase 4; PMCA1; PMCA2; PMCA3; PMCA4; sarcolemmal calcium pump; wriggle

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Gene Aliases: 2810442I22Rik; 6430519O13Rik; ATP2B1; ATP2B2; ATP2B3; ATP2B4; CFAP39; CLA2; D6Abb2e; dfw; E130111D10Rik; Gena300; jog; MXRA1; OPCA; PMCA1; Pmca1a; Pmca1b; Pmca1c; PMCA1kb; PMCA2; PMCA2a; PMCA2i; PMCA3; PMCA3a; PMCA4; PMCA4b; PMCA4x; SCAX1; Tmy; wms; wri

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UniProt ID: (Human) P20020, (Human) Q01814, (Human) Q16720, (Human) P23634, (Mouse) G5E829, (Rat) P11505, (Rat) P11506, (Mouse) Q9R0K7, (Rat) Q64568, (Rat) Q64542, (Mouse) Q6Q477

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Entrez Gene ID: (Human) 490, (Human) 491, (Human) 492, (Human) 493, (Mouse) 67972, (Rat) 29598, (Rat) 24215, (Mouse) 11941, (Rat) 29599, (Mouse) 320707, (Rat) 29600, (Mouse) 381290

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Function(s)
calcium-transporting ATPase activity protein binding calmodulin binding ATP binding PDZ domain binding metal ion binding calcium-dependent ATPase activity sodium channel regulator activity protein phosphatase 2B binding nitric-oxide synthase inhibitor activity nitric-oxide synthase binding scaffold protein binding nucleotide binding hydrolase activity calcium ion binding protein C-terminus binding acetylcholine receptor binding glutamate receptor binding primary active transporter
Process(es)
neural retina development transport cellular calcium ion homeostasis brain development aging response to cold ion transmembrane transport calcium ion transmembrane transport cellular response to vitamin D cellular response to corticosterone stimulus calcium ion export regulation of cardiac conduction calcium ion transport organelle organization lactation sensory perception of sound locomotory behavior regulation of cell size cerebellar Purkinje cell differentiation cerebellar granule cell differentiation neuron differentiation locomotion serotonin metabolic process otolith mineralization cGMP metabolic process regulation of synaptic plasticity synapse organization neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport auditory receptor cell stereocilium organization cochlea development regulation of transcription from RNA polymerase II promoter spermatogenesis negative regulation of nitric oxide mediated signal transduction hippocampus development sperm motility positive regulation of peptidyl-serine phosphorylation negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity response to hydrostatic pressure negative regulation of calcineurin-NFAT signaling cascade cellular response to epinephrine stimulus calcium ion transmembrane import into cytosol calcium ion import across plasma membrane negative regulation of the force of heart contraction negative regulation of arginine catabolic process negative regulation of adrenergic receptor signaling pathway involved in heart process negative regulation of peptidyl-cysteine S-nitrosylation regulation of sodium ion transmembrane transport regulation of cell cycle G1/S phase transition negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of citrulline biosynthetic process positive regulation of cAMP-dependent protein kinase activity ion transport metabolic process cell morphogenesis cerebellum development cerebellar Purkinje cell layer morphogenesis inner ear morphogenesis inner ear development inner ear receptor cell differentiation
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