Product References
Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo.
Nature communications
Tao Y,Lamas V,Du W,Zhu W,Li Y,Whittaker MN,Zuris JA,Thompson DB,Rameshbabu AP,Shu Y,Gao X,Hu JH,Pei C,Kong WJ,Liu X,Wu H,Kleinstiver BP,Liu DR,Chen ZY
PA1-915 was used in Immunohistochemistry-immunofluorescence to suggest that liposome-RNP delivery can be used as a strategy to recover hearing with dominant mutations in OHC genes and with digenic mutations in the auditory hair cells, potentially expanding therapeutics of gene editing to treat hearing loss.
Tue Aug 15 00:00:00 EDT 2023
Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2.
Neuron
Martín-de-Saavedra MD,Dos Santos M,Culotta L,Varea O,Spielman BP,Parnell E,Forrest MP,Gao R,Yoon S,McCoig E,Jalloul HA,Myczek K,Khalatyan N,Hall EA,Turk LS,Sanz-Clemente A,Comoletti D,Lichtenthaler SF,Burgdorf JS,Barbolina MV,Savas JN,Penzes P
PA1-915 was used in Immunoprecipitation to identify the plasma membrane Ca2+ ATPase (PMCA) extrusion pumps as novel CNTNAP2-ecto binding partners.
Wed Feb 16 00:00:00 EST 2022
MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells.
Cell reports
Jeong J,Shin JH,Li W,Hong JY,Lim J,Hwang JY,Chung JJ,Yan Q,Liu Y,Choi J,Wysolmerski J
PA1-915 was used in Immunocytochemistry, Western Blot to show that MAL2-mediated lipid raft formation leads to HER2 plasma membrane retention and enhanced HER2 signaling in breast cancer cells.
Tue Dec 28 00:00:00 EST 2021
MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells.
Cell reports
Jeong J,Shin JH,Li W,Hong JY,Lim J,Hwang JY,Chung JJ,Yan Q,Liu Y,Choi J,Wysolmerski J
PA1-915 was used in Immunocytochemistry, Western Blot to show that MAL2-mediated lipid raft formation leads to HER2 plasma membrane retention and enhanced HER2 signaling in breast cancer cells.
Tue Dec 28 00:00:00 EST 2021
MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells.
Cell reports
Jeong J,Shin JH,Li W,Hong JY,Lim J,Hwang JY,Chung JJ,Yan Q,Liu Y,Choi J,Wysolmerski J
PA1-915 was used in Immunocytochemistry, Western Blot to show that MAL2-mediated lipid raft formation leads to HER2 plasma membrane retention and enhanced HER2 signaling in breast cancer cells.
Tue Dec 28 00:00:00 EST 2021
MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells.
Cell reports
Jeong J,Shin JH,Li W,Hong JY,Lim J,Hwang JY,Chung JJ,Yan Q,Liu Y,Choi J,Wysolmerski J
PA1-915 was used in Immunocytochemistry, Western Blot to show that MAL2-mediated lipid raft formation leads to HER2 plasma membrane retention and enhanced HER2 signaling in breast cancer cells.
Tue Dec 28 00:00:00 EST 2021
Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period.
Reproduction (Cambridge, England)
Laezer I,Palma-Vera SE,Liu F,Frank M,Trakooljul N,Vernunft A,Schoen J,Chen S
PA1-915 was used in Western Blotting to study the extracellular vesicle profile in porcine oviductal fluid.
Wed Apr 01 00:00:00 EDT 2020
Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer.
Cancers
Sritangos P,Pena Alarcon E,James AD,Sultan A,Richardson DA,Bruce JIE
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Western Blot
Thu Jan 16 00:00:00 EST 2020
Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
Life science alliance
Colaco A,Fernández-Suárez ME,Shepherd D,Gal L,Bibi C,Chuartzman S,Diot A,Morten K,Eden E,Porter FD,Poulton J,Platt N,Schuldiner M,Platt FM
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Western Blot
Wed Jul 01 00:00:00 EDT 2020
Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
Life science alliance
Colaco A,Fernández-Suárez ME,Shepherd D,Gal L,Bibi C,Chuartzman S,Diot A,Morten K,Eden E,Porter FD,Poulton J,Platt N,Schuldiner M,Platt FM
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Western Blot
Wed Jul 01 00:00:00 EDT 2020
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
Nature
Gao X,Tao Y,Lamas V,Huang M,Yeh WH,Pan B,Hu YJ,Hu JH,Thompson DB,Shu Y,Li Y,Wang H,Yang S,Xu Q,Polley DB,Liberman MC,Kong WJ,Holt JR,Chen ZY,Liu DR
PA1-915 was used in Functional assays to study the treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
Thu Jan 11 00:00:00 EST 2018
Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease.
Molecular psychiatry
Pérez-Cañamás A,Benvegnù S,Rueda CB,Rábano A,Satrústegui J,Ledesma MD
PA1915 was used in western blot to investigate how sphingomyelin influence neural pathology in a mouse model of Niemann-Pick disease type A
Mon May 01 00:00:00 EDT 2017
Maintenance of neuronal size gradient in MNTB requires sound-evoked activity.
Journal of neurophysiology
Weatherstone JH,Kopp-Scheinpflug C,Pilati N,Wang Y,Forsythe ID,Rubel EW,Tempel BL
PA1915 was used in immunohistochemistry - frozen section to propose that PMCA2 is not required for medial nucleus of the trapezoid body neuron survival and investigate other factors that contribute to their survival
Wed Feb 01 00:00:00 EST 2017
HER2 signaling regulates HER2 localization and membrane retention.
PloS one
Jeong J,Kim W,Kim LK,VanHouten J,Wysolmerski JJ
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Western Blot
Wed Aug 30 00:00:00 EDT 2017
HER2 signaling regulates HER2 localization and membrane retention.
PloS one
Jeong J,Kim W,Kim LK,VanHouten J,Wysolmerski JJ
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Western Blot
Wed Aug 30 00:00:00 EDT 2017
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.
The Journal of biological chemistry
Jeong J,VanHouten JN,Kim W,Dann P,Sullivan C,Choi J,Sneddon WB,Friedman PA,Wysolmerski JJ
PA1915 was used in immunocytochemistry, immunoprecipitation, and western blot to show that NHERF1 and PMCA2 modulate HER2 signaling and membrane retention in breast cancers
Fri Apr 21 00:00:00 EDT 2017
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.
The Journal of biological chemistry
Jeong J,VanHouten JN,Kim W,Dann P,Sullivan C,Choi J,Sneddon WB,Friedman PA,Wysolmerski JJ
PA1915 was used in immunocytochemistry, immunoprecipitation, and western blot to show that NHERF1 and PMCA2 modulate HER2 signaling and membrane retention in breast cancers
Fri Apr 21 00:00:00 EDT 2017
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.
The Journal of biological chemistry
Jeong J,VanHouten JN,Kim W,Dann P,Sullivan C,Choi J,Sneddon WB,Friedman PA,Wysolmerski JJ
PA1915 was used in immunocytochemistry, immunoprecipitation, and western blot to show that NHERF1 and PMCA2 modulate HER2 signaling and membrane retention in breast cancers
Fri Apr 21 00:00:00 EDT 2017
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.
The Journal of biological chemistry
Jeong J,VanHouten JN,Kim W,Dann P,Sullivan C,Choi J,Sneddon WB,Friedman PA,Wysolmerski JJ
PA1915 was used in immunocytochemistry, immunoprecipitation, and western blot to show that NHERF1 and PMCA2 modulate HER2 signaling and membrane retention in breast cancers
Fri Apr 21 00:00:00 EDT 2017
Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction.
Frontiers in cellular neuroscience
Lisek M,Ferenc B,Studzian M,Pulaski L,Guo F,Zylinska L,Boczek T
PA1-915 was used in Western Blotting to characterize brain region-specific effects of ketamine on PMCA activity.
Thu Oct 01 00:00:00 EDT 2020
Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system.
BMC molecular biology
Minich RR,Li J,Tempel BL
PA1-915 was used in Electrophoretic mobility shift assay to elucidate the transcriptional regulatory mechanisms and transcriptional factors modulating α-plasma membrane calcium ATPase 2 (Atp2b2) expression in the brain.
Mon May 22 00:00:00 EDT 2017
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
Proceedings of the National Academy of Sciences of the United States of America
Jeong J,VanHouten JN,Dann P,Kim W,Sullivan C,Yu H,Liotta L,Espina V,Stern DF,Friedman PA,Wysolmerski JJ
PA1-915 was used in immunocytochemistry and western blot to study the interactions between PMCA2 and HER2 in breast cancer cells
Tue Jan 19 00:00:00 EST 2016
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
Proceedings of the National Academy of Sciences of the United States of America
Jeong J,VanHouten JN,Dann P,Kim W,Sullivan C,Yu H,Liotta L,Espina V,Stern DF,Friedman PA,Wysolmerski JJ
PA1-915 was used in immunocytochemistry and western blot to study the interactions between PMCA2 and HER2 in breast cancer cells
Tue Jan 19 00:00:00 EST 2016
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
Proceedings of the National Academy of Sciences of the United States of America
Jeong J,VanHouten JN,Dann P,Kim W,Sullivan C,Yu H,Liotta L,Espina V,Stern DF,Friedman PA,Wysolmerski JJ
PA1-915 was used in immunocytochemistry and western blot to study the interactions between PMCA2 and HER2 in breast cancer cells
Tue Jan 19 00:00:00 EST 2016
The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.
Scientific reports
Peters AA,Milevskiy MJ,Lee WC,Curry MC,Smart CE,Saunus JM,Reid L,da Silva L,Marcial DL,Dray E,Brown MA,Lakhani SR,Roberts-Thomson SJ,Monteith GR
PA1-915 was used in immunohistochemistry - paraffin section to investigate the regulation of breast cancer cell proliferation and sensitivity to doxorubicin through the calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2)
Thu May 05 00:00:00 EDT 2016
Changes in cochlear PMCA2 expression correlate with the maturation of auditory sensitivity.
Journal of the Association for Research in Otolaryngology : JARO
Watson CJ,Lies SM,Minich RR,Tempel BL
PA1-915 was used in western blot to study the relationship between auditory sensitivity maturation and the expression of PMCA2 in a murine model
Fri Aug 01 00:00:00 EDT 2014
A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.
Hearing research
Watson CJ,Tempel BL
PA1-915 was used in immunohistochemistry to study the interactions of Cdh23 and an unidentified hearing loss gene with a novel Atp2b2 deafwaddler allele of the plasma membrane Ca(2+)-ATPase 2
Tue Oct 01 00:00:00 EDT 2013
Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yang J,Bouvron S,Lv P,Chi F,Yamoah EN
PA1-915 was used in Immunohistochemistry-immunofluorescence to identify that Atoh1 mediates trans-differentiation of "ancestral" hair cells that are likely to undergo diversification in an endorgan-specific manner.
Wed Mar 14 00:00:00 EDT 2012
PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gómez-Varela D,Schmidt M,Schoellerman J,Peters EC,Berg DK
PA1-915 was used in immunocytochemistry to study the mechanism by which plasma membrane calcium-ATPase pump isoform 2 controls calcium signaling in neurons
Wed May 16 00:00:00 EDT 2012
The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.
The European journal of neuroscience
Chen Q,Mahendrasingam S,Tickle JA,Hackney CM,Furness DN,Fettiplace R
PA1-915 was used in immunohistochemistry to study the localization and function of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells
Wed Aug 01 00:00:00 EDT 2012
Interaction of plasma membrane Ca(2+)-ATPase isoform 4 with calcineurin A: implications for catecholamine secretion by PC12 cells.
Biochemical and biophysical research communications
Kosiorek M,Podszywalow-Bartnicka P,Zylinska L,Zablocki K,Pikula S
PA1-915 was used in immunoprecipitation to study the interaction of calcineurin A with PMCA4 and its effect on catecholamine secretion
Fri Jul 29 00:00:00 EDT 2011
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
The Journal of biological chemistry
Bortolozzi M,Brini M,Parkinson N,Crispino G,Scimemi P,De Siati RD,Di Leva F,Parker A,Ortolano S,Arslan E,Brown SD,Carafoli E,Mammano F
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Fri Nov 26 00:00:00 EST 2010
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
The Journal of biological chemistry
Bortolozzi M,Brini M,Parkinson N,Crispino G,Scimemi P,De Siati RD,Di Leva F,Parker A,Ortolano S,Arslan E,Brown SD,Carafoli E,Mammano F
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Fri Nov 26 00:00:00 EST 2010
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
The Journal of biological chemistry
Bortolozzi M,Brini M,Parkinson N,Crispino G,Scimemi P,De Siati RD,Di Leva F,Parker A,Ortolano S,Arslan E,Brown SD,Carafoli E,Mammano F
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Fri Nov 26 00:00:00 EST 2010
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
The Journal of biological chemistry
Bortolozzi M,Brini M,Parkinson N,Crispino G,Scimemi P,De Siati RD,Di Leva F,Parker A,Ortolano S,Arslan E,Brown SD,Carafoli E,Mammano F
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Fri Nov 26 00:00:00 EST 2010
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
The Journal of biological chemistry
Bortolozzi M,Brini M,Parkinson N,Crispino G,Scimemi P,De Siati RD,Di Leva F,Parker A,Ortolano S,Arslan E,Brown SD,Carafoli E,Mammano F
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Fri Nov 26 00:00:00 EST 2010
Effects of paraquat-induced oxidative stress on the neuronal plasma membrane Ca(2+)-ATPase.
Free radical biology & medicine
Zaidi A,Fernandes D,Bean JL,Michaelis ML
PA1-915 was used in western blot to study how the intracellular redox cycling agent paraquat affects the functions of PMCA in primary cortical neurons
Sun Nov 15 00:00:00 EST 2009
Compartment-specific regulation of plasma membrane calcium ATPase type 2 in the chick auditory brainstem.
The Journal of comparative neurology
Wang Y,Cunningham DE,Tempel BL,Rubel EW
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Sat Jun 20 00:00:00 EDT 2009
Compartment-specific regulation of plasma membrane calcium ATPase type 2 in the chick auditory brainstem.
The Journal of comparative neurology
Wang Y,Cunningham DE,Tempel BL,Rubel EW
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Sat Jun 20 00:00:00 EDT 2009
Compartment-specific regulation of plasma membrane calcium ATPase type 2 in the chick auditory brainstem.
The Journal of comparative neurology
Wang Y,Cunningham DE,Tempel BL,Rubel EW
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Sat Jun 20 00:00:00 EDT 2009
Localization of plasma membrane and secretory calcium pumps in the mammary gland.
Biochemical and biophysical research communications
Faddy HM,Smart CE,Xu R,Lee GY,Kenny PA,Feng M,Rao R,Brown MA,Bissell MJ,Roberts-Thomson SJ,Monteith GR
PA1-915 was used in immunocytochemistry and immunohistochemistry to investigate the cellular distribution of plasma membrane and secretory calcium ATPase in mouse mammary gland
Fri May 09 00:00:00 EDT 2008
Localization of plasma membrane and secretory calcium pumps in the mammary gland.
Biochemical and biophysical research communications
Faddy HM,Smart CE,Xu R,Lee GY,Kenny PA,Feng M,Rao R,Brown MA,Bissell MJ,Roberts-Thomson SJ,Monteith GR
PA1-915 was used in immunocytochemistry and immunohistochemistry to investigate the cellular distribution of plasma membrane and secretory calcium ATPase in mouse mammary gland
Fri May 09 00:00:00 EDT 2008
The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk.
Endocrinology
VanHouten JN,Neville MC,Wysolmerski JJ
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunohistochemistry
Sat Dec 01 00:00:00 EST 2007
The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk.
Endocrinology
VanHouten JN,Neville MC,Wysolmerski JJ
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunohistochemistry
Sat Dec 01 00:00:00 EST 2007
The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk.
Endocrinology
VanHouten JN,Neville MC,Wysolmerski JJ
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunohistochemistry
Sat Dec 01 00:00:00 EST 2007
Plasma membrane calcium pumps in mouse olfactory sensory neurons.
Chemical senses
Weeraratne SD,Valentine M,Cusick M,Delay R,Van Houten JL
Published figure using PMCA2 ATPase polyclonal antibody (Product # PA1-915) in Immunofluorescence
Sun Oct 01 00:00:00 EDT 2006
The plasma membrane Ca2+-ATPase isoform 4 is localized in lipid rafts of cerebellum synaptic plasma membranes.
The Journal of biological chemistry
Sepúlveda MR,Berrocal-Carrillo M,Gasset M,Mata AM
PA1-915 was used in western blot to localize the plasma membrane calcium-ATPase isoform 4.
Fri Jan 06 00:00:00 EST 2006
Developmental assembly of transduction apparatus in chick basilar papilla.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Si F,Brodie H,Gillespie PG,Vazquez AE,Yamoah EN
PA1-915 was used in immunocytochemistry to study the developmental assembly of the transduction apparatus in chick hair cells.
Wed Nov 26 00:00:00 EST 2003
Regional distribution of Na,K-ATPase activity in porcine lens epithelium.
Investigative ophthalmology & visual science
Tamiya S,Dean WL,Paterson CA,Delamere NA
PA1-915 was used in western blot to investigate the sodium/potassium ATPase protein expression in porcine lens epithelium.
Wed Oct 01 00:00:00 EDT 2003
