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Positive test controls include: HepG2, A-549, HeLa, 293T, NIH/3T3, Mouse liver, Mouse intestine, Rat brain. The target is usually found in the following locations: Cytoplasm.
Immunogen sequence: MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE KVQEQLGNDV VEKYDYVFPE NGLVAYKDGK LLCRQNIQSH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDKK ENIRQKFVAD LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLRHVENDG YKTIYFFGDK TMPGGNDHEI FTDPRTMGYS VTAPEDTRRI CELLFS
The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mannose-6-phosphate isomerase; Phosphomannomutase 2; phosphomannose isomerase 1; PMM 2
Gene Aliases: AI585868; C86848; CDG1; CDG1a; CDGS; PMI; PMI1; PMM 2; PMM2
UniProt ID: (Human) O15305, (Mouse) Q9Z2M7
Entrez Gene ID: (Human) 5373, (Mouse) 54128, (Rat) 302915
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