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Sequence of this protein is as follows: RYAGLLFSSR PDAHDRMDCK GLEAVRRDNC PLVANLVTAS LRRLLIDRDP EGAVAHAQDV ISDLLCNRID ISQLVITKEL TRAASDYAGK QAHVELAERM RKRDPGSAPS LGDRVPYVII SAAKGVAAYM KSEDPLFVLE HSLPIDTQYY LEQQLAKPLL RIFEPILGEG RAEAVLLRGD HTRCKTVLTG KVGGLLAFAK RRNCCIGCRT VLSHQGAVCE FCQPRESELY QKEVSHLNAL EERFSRLWTQ CQRCQGSLHE DVICTSRDCP IFYMRKKVRK DLEDQEQLLR RFGPPGPEAW
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
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