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Product Details
16423-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
POLR3H Fusion Protein Ag9624 (1-175 aa encoded by BC017248)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MFVLVEMVD TVRIPPWQFE RKLNDSIAEE LNKKLANKVV YNVGLCICLF DITKLEDAYV FPGDGASHTK VSLGFFDDIL IPPESLQQPA KFDEAEQVWV WEYETEEGAH DLYMDTGEEI RFRVVDESFV DTSPTGPSSA DATTSSEELP KKEAPYTLVG SISEPGLGLL SWWTSN (1-175 aa encoded by B C017248)
Target Information
RPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide; DNA-directed RNA polymerase III subunit H; DNA-directed RNA polymerase III subunit RPC8; polymerase (RNA) III (DNA directed) polypeptide H (22.9kD); polymerase (RNA) III subunit H; RNA nucleotidyltransferase (DNA-directed); RNA polymerase III subunit 22.9 kDa subunit; RNA polymerase III subunit C7; RNA polymerase III subunit C8; RPC22.9
Gene Aliases: 5031409G22Rik; KIAA1665; POLR3H; RPC22.9; RPC8
UniProt ID: (Human) Q9Y535, (Mouse) Q9D2C6
Entrez Gene ID: (Human) 171568, (Mouse) 78929, (Rat) 300088
nucleobase-containing compound metabolic process
transcription from RNA polymerase III promoter
transcription initiation from RNA polymerase III promoter
positive regulation of type I interferon production
innate immune response
defense response to virus
immune system process
transcription, DNA-templated
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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