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Invitrogen
PP2A alpha Polyclonal Antibody
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
Product Details
PA5-17510
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids at the carboxy terminus of human PP2A catalytic subunit
Conjugate
Form
Liquid
Concentration
27 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10983779
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other PP2A subunits.
Target Information
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. The PP2A family comprises subfamily members PP2A alpha and PP2A beta. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B55-GAMMA; IMYPNO; Methyl-PPP2CA; MGC33570; PP2A alpha; PP2A C terminal; PP2A L9; PP2A Leucine 9; PP2A-alpha; PR52; PR55G; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase-2A-alpha; Replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Aliases: PP2A; Pp2a1; PP2Ac; PP2CA; PP2Calpha; PPP2CA; R75353; RP-C
UniProt ID: (Human) P67775, (Mouse) P63330, (Rat) P63331
Entrez Gene ID: (Human) 5515, (Mouse) 19052, (Rat) 24672
phosphoprotein phosphatase activity
protein binding
protein C-terminus binding
metal ion binding
GABA receptor binding
protein serine/threonine phosphatase activity
hydrolase activity
enzyme binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
protein complex binding
protein kinase B binding
ion channel binding
protein dimerization activity
tau protein binding
protein phosphatase 2A binding
protein antigen binding
protein heterodimerization activity
protein phosphatase
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
inactivation of MAPK activity
regulation of DNA replication
regulation of transcription, DNA-templated
protein dephosphorylation
ceramide metabolic process
apoptotic process
mitotic nuclear envelope reassembly
mesoderm development
RNA splicing
response to organic substance
negative regulation of epithelial to mesenchymal transition
second-messenger-mediated signaling
regulation of Wnt signaling pathway
regulation of cell adhesion
negative regulation of cell growth
regulation of growth
negative regulation of tyrosine phosphorylation of Stat3 protein
regulation of cell differentiation
meiotic cell cycle
positive regulation of protein serine/threonine kinase activity
negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
negative regulation of protein phosphorylation
regulation of receptor activity
regulation of protein autophosphorylation
positive regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
regulation of protein catabolic process
negative regulation of transcription factor import into nucleus
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cell cycle
protein heterotrimerization
cellular response to glucose stimulus
negative regulation of calcium ion transmembrane transporter activity
cardiac ventricle development
heart development
cellular response to insulin stimulus
cellular response to calcium ion
cellular response to cytokine stimulus
cellular response to ethanol
cellular response to follicle-stimulating hormone stimulus
cellular response to steroid hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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