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Product Details
28053-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPARD Fusion Protein Ag27817
Conjugate
Form
Liquid
Concentration
333 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta
Gene Aliases: FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB; PPARD
UniProt ID: (Human) Q03181
Entrez Gene ID: (Human) 5467
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
drug binding
zinc ion binding
lipid binding
sequence-specific DNA binding
protein heterodimerization activity
NF-kappaB binding
linoleic acid binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
glucose metabolic process
proteoglycan metabolic process
generation of precursor metabolites and energy
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
lipid metabolic process
fatty acid beta-oxidation
vitamin A metabolic process
apoptotic process
heart development
embryo implantation
cholesterol metabolic process
cell proliferation
axon ensheathment
phospholipid biosynthetic process
fatty acid catabolic process
mRNA transcription
response to glucose
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
regulation of skeletal muscle satellite cell proliferation
negative regulation of smooth muscle cell migration
glucose transport
fatty acid transport
cell differentiation
negative regulation of cell growth
intracellular receptor signaling pathway
cell-substrate adhesion
positive regulation of insulin secretion
negative regulation of collagen biosynthetic process
response to vitamin A
wound healing
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
positive regulation of skeletal muscle tissue regeneration
keratinocyte proliferation
positive regulation of fat cell differentiation
negative regulation of myoblast differentiation
positive regulation of epidermis development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
decidualization
negative regulation of smooth muscle cell proliferation
negative regulation of epithelial cell proliferation
negative regulation of inflammatory response
keratinocyte migration
adipose tissue development
cellular response to lipopolysaccharide
cellular response to hypoxia
apoptotic signaling pathway
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of myoblast proliferation
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