OriGene

PPARD Monoclonal Antibody (OTI2D2), TrueMAB™

View all (24) PPAR delta antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

TA811236

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI2D2

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-244 of human PPARD produced in E.coli.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; PPARdelta/beta

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Gene Aliases: FAAR; NR1C2; NUC-1; NUC1; NUCI; NUCII; PPAR-beta; PPAR-delta; PPAR[b]; PPARB; Pparb/d; PPARD; PPARdelta

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UniProt ID: (Human) Q03181, (Mouse) P35396

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Entrez Gene ID: (Human) 5467, (Mouse) 19015

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Function(s)
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding transcription factor binding drug binding zinc ion binding lipid binding sequence-specific DNA binding protein heterodimerization activity NF-kappaB binding linoleic acid binding fatty acid binding enzyme activator activity prostacyclin receptor activity metal ion binding retinoid X receptor binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter glucose metabolic process proteoglycan metabolic process generation of precursor metabolites and energy regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid beta-oxidation vitamin A metabolic process apoptotic process heart development embryo implantation cholesterol metabolic process cell proliferation axon ensheathment phospholipid biosynthetic process fatty acid catabolic process mRNA transcription response to glucose positive regulation of phosphatidylinositol 3-kinase signaling response to activity regulation of skeletal muscle satellite cell proliferation negative regulation of smooth muscle cell migration glucose transport fatty acid transport cell differentiation negative regulation of cell growth intracellular receptor signaling pathway cell-substrate adhesion positive regulation of insulin secretion negative regulation of collagen biosynthetic process response to vitamin A wound healing negative regulation of apoptotic process steroid hormone mediated signaling pathway positive regulation of skeletal muscle tissue regeneration keratinocyte proliferation positive regulation of fat cell differentiation negative regulation of myoblast differentiation positive regulation of epidermis development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasodilation decidualization negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response keratinocyte migration adipose tissue development cellular response to lipopolysaccharide cellular response to hypoxia apoptotic signaling pathway negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of myoblast proliferation placenta development transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter G-protein coupled receptor signaling pathway positive regulation of cell proliferation epidermis development cellular process fatty acid oxidation regulation of cell proliferation anagen positive regulation of catalytic activity regulation of fat cell differentiation regulation of insulin secretion
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