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OriGene
PPIF Monoclonal Antibody (OTI4D3), TrueMAB™
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
PPIF Antibody (TA809066) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPIF (RC223397, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PPIF. (1. Positive lysates LY417109 (100 µg) and LC417109 (20 µg) can be purchased separately from OriGene.
Product Details
TA809066
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4D3
Immunogen
Full length human recombinant protein of human PPIF produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclophilin 3; Cyclophilin D; Cyclophilin F; CyP-D; CyP-M; Mitochondrial cyclophilin; mitochondrial peptidyl-prolyl cis-trans isomerase; Peptidyl-prolyl cis-trans isomerase F; Peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; PPIase F; Rotamase F
Gene Aliases: Cyp-D; CyP-M; CYP3; CypD; PPIF
UniProt ID: (Human) P30405
Entrez Gene ID: (Human) 10105
protein peptidyl-prolyl isomerization
response to ischemia
protein folding
apoptotic mitochondrial changes
regulation of proton-transporting ATPase activity, rotational mechanism
regulation of necrotic cell death
negative regulation of ATPase activity
negative regulation of apoptotic process
regulation of mitochondrial membrane permeability
necroptotic process
cellular response to hydrogen peroxide
cellular response to arsenic-containing substance
cellular response to calcium ion
positive regulation of release of cytochrome c from mitochondria
negative regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
negative regulation of oxidative phosphorylation uncoupler activity
negative regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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