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Immunogen sequence: MTELKAKGP RAPHVAGGPP SPEVGSPLLC RPAAGPFPGS QTSDTLPEVS AIPISLDGLL FPRPCQGQDP SDEKTQDQQS LSDVEGAYSR AEATRGAGGS SSSPPEKDSG LLDSVLDTLL APSGPGQSQP SPPACEVTSS WCLFGPELPE DPPAAPATQR VLSPLMSRSG CKVGDSSGTA AAHKVLPRGL SPARQLLLPA SESPHWSGAP VKPSPQAAAV EVEEEDGSES EESAGPLLKG KPRALGGAAA GGGAAAVPPG AAAGGVALVP KEDSRFSAPR VALVEQDAPM APGRSPLATT VM (1-301 aa encoded by NM_000926)
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
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Protein Aliases: Nuclear receptor subfamily 3 group C member 3; PR; Progesterone receptor
Gene Aliases: 9930019P03Rik; BB114106; ENSMUSG00000074510; NR3C3; PGR; PR; PR-A; PR-B
UniProt ID: (Human) P06401, (Mouse) Q00175
Entrez Gene ID: (Human) 5241, (Mouse) 18667
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