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PRC1 Antibody (PA5-101025) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded PRC1 in mouse lung tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with PRC1 polyclonal antibody (Product # PA5-101025) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-101025
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRC1(Accession O43663), corresponding to amino acid residues Q448-A498.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850494
Product Specific Information
Antibody detects endogenous levels of total PRC1.
Target Information
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anaphase spindle elongation 1 homolog; MGC1671; MGC3669; PRC1; protein regulating cytokinesis 1; Protein regulator of cytokinesis 1
Gene Aliases: ASE1; D7Ertd348e; PRC1
UniProt ID: (Human) O43663, (Mouse) Q99K43
Entrez Gene ID: (Human) 9055, (Mouse) 233406, (Rat) 308761
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