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Product Details
H00000639-M10
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1G9
Immunogen
PRDM1 (NP_001189, 422 a.a. approximately 493 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: HPMLNPTSLP SSLPSDGARR LLQPEHPREV LVPAPHSAFS FTGAAASMKD KACSPTSGSP TAGTAATAEH V
Target Information
Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; BLIMP-1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI BF1; PRDI-BF1; PRDI-binding factor-1; RP1-134E15.1
Gene Aliases: BLIMP1; PRDI-BF1; PRDM1
UniProt ID: (Human) O75626
Entrez Gene ID: (Human) 639
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
methyltransferase activity
histone deacetylase binding
metal ion binding
promoter-specific chromatin binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
morphogenesis of a branching structure
maternal placenta development
heart valve development
ventricular septum development
transcription, DNA-templated
germ cell development
post-embryonic development
positive regulation of gene expression
negative regulation of B cell proliferation
negative regulation of lipopolysaccharide-mediated signaling pathway
methylation
regulation of natural killer cell differentiation
regulation of extrathymic T cell differentiation
aorta development
eye photoreceptor cell development
cell fate commitment
positive regulation of B cell differentiation
artery morphogenesis
regulation of NK T cell differentiation
intestinal epithelial cell development
trophoblast giant cell differentiation
coronary vasculature development
sebum secreting cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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