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PRDX2 Antibody (MA5-50857) in WB
Western blot analysis of PRDX2 in various lysates. Samples were incubated with PRDX2 monoclonal antibody (Product # MA5-50857) using a dilution of 2 μg/mL followed by HRP-Linked Rabbit Anti-Mouse IgG secondary antibody at a dilution of 0.2 µg/mL. Lane 1: Rat Lung lysate; Lane 2: Rat Kidney lysate; Lane 3: Rat Spinal cord lysate.
Product Details
MA5-50857
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
C2
Immunogen
Recombinant Human PRDX2 protein, Ala2-Asn198 (Accession #P32119)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3093369
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 2a; HGNC:9353; MGC4104; Natural killer cell-enhancing factor B; NKEF-B; Peroxiredoxin-2; PRP; thiol-specific antioxidant 1; Thiol-specific antioxidant protein; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2; torin; TSA
Gene Aliases: HEL-S-2a; NKEF-B; NKEFB; PRDX2; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA
UniProt ID: (Human) P32119, (Rat) P35704
Entrez Gene ID: (Human) 7001, (Rat) 29338
response to reactive oxygen species
response to oxidative stress
removal of superoxide radicals
cellular response to oxidative stress
hydrogen peroxide catabolic process
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
oxidation-reduction process
activation of MAPK activity
respiratory burst involved in inflammatory response
regulation of hydrogen peroxide metabolic process
positive regulation of blood coagulation
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
response to lipopolysaccharide
T cell proliferation
hydrogen peroxide metabolic process
negative regulation of T cell differentiation
thymus development
homeostasis of number of cells
negative regulation of reactive oxygen species metabolic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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