Proteintech

PRDX4 Polyclonal Antibody

PRDX4 Antibody in Immunocytochemistry (ICC/IF)

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PRDX4 Antibody (10703-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using PRDX4 antibody (Product # 10703-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PRDX4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRDX4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10703-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRDX4 Fusion Protein Ag1177 (1-271 aa encoded by BC007107)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to PRDX4.

Immunogen sequence: MEALPLLAA TTPDHGRHRR LLLLPLLLFL LPAGAVQGWE TEERPRTREE ECHFYAGGQV YPGEASRVSV ADHSLHLSKA KISKPAPYWE GTAVIDGEFK ELKLTDYRGK YLVFFFYPLD FTFVCPTEII AFGDRLEEFR SINTEVVACS VDSQFTHLAW INTPRRQGGL GPIRIPLLSD LTHQISKDYG VYLEDSGHTL RGLFIIDDKG ILRQITLNDL PVGRSVDETL RLVQAFQYTD KHGEVCPAGW KPGSETIIPD PAGKLKYFDK LN (1-271 aa encoded by BC007107)

Target Information

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.

Clinical immunology (Orlando, Fla.)

Aihaiti Y,Tuerhong X,Zheng H,Cai Y,Yang M,Xu P

Fri Apr 01 00:00:00 EDT 2022

Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.

Clinical immunology (Orlando, Fla.)

Aihaiti Y,Tuerhong X,Zheng H,Cai Y,Yang M,Xu P

Fri Apr 01 00:00:00 EDT 2022

Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.

Clinical immunology (Orlando, Fla.)

Aihaiti Y,Tuerhong X,Zheng H,Cai Y,Yang M,Xu P

Fri Apr 01 00:00:00 EDT 2022

Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.

Journal of agricultural and food chemistry

Chen Y,Zhang H,Li Y,Ji S,Jia P,Wang T

Wed Oct 26 00:00:00 EDT 2022

Sulfiredoxin Promotes Cancer Cell Invasion through Regulation of the miR143-Fascin Axis.

Molecular and cellular biology

Jiang H,Thapa P,Ding N,Hao Y,Alshahrani A,Wang C,Evers BM,Wei Q

Thu May 19 00:00:00 EDT 2022

Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE^-/- Mouse Model.

Cells

Längst N,Adler J,Kuret A,Peter A,Ruth P,Boldt K,Lukowski R

Sun Apr 17 00:00:00 EDT 2022

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.

Nature communications

Vdovin A,Jelinek T,Zihala D,Sevcikova T,Durech M,Sahinbegovic H,Snaurova R,Radhakrishnan D,Turi M,Chyra Z,Popkova T,Venglar O,Hrdinka M,Hajek R,Simicek M

Thu Nov 10 00:00:00 EST 2022

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.

Nature communications

Vdovin A,Jelinek T,Zihala D,Sevcikova T,Durech M,Sahinbegovic H,Snaurova R,Radhakrishnan D,Turi M,Chyra Z,Popkova T,Venglar O,Hrdinka M,Hajek R,Simicek M

Thu Nov 10 00:00:00 EST 2022

Endoplasmic reticulum oxidoreductase 1 alpha modulates prostate cancer hallmarks.

Translational andrology and urology

Cornelius J,Cavarretta I,Pozzi E,Lavorgna G,Locatelli I,Tempio T,Montorsi F,Mattei A,Sitia R,Salonia A,Anelli T

Mon Mar 01 00:00:00 EST 2021

Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice.

Scientific reports

Homma T,Kurahashi T,Ishii N,Shirasawa N,Fujii J

Wed Oct 21 00:00:00 EDT 2020

Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice.

Scientific reports

Homma T,Kurahashi T,Ishii N,Shirasawa N,Fujii J

Wed Oct 21 00:00:00 EDT 2020

Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice.

Scientific reports

Homma T,Kurahashi T,Ishii N,Shirasawa N,Fujii J

Wed Oct 21 00:00:00 EDT 2020

Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhao L,Zhao J,Gao R,Tian Y,Zhang Y,Tang W,Jiang Y,Li C,Wang M,Yang F,Li G

Sun Mar 01 00:00:00 EST 2020

A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.

The FEBS journal

Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A

Wed Jan 01 00:00:00 EST 2020

A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.

The FEBS journal

Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A

Wed Jan 01 00:00:00 EST 2020

A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.

The FEBS journal

Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A

Wed Jan 01 00:00:00 EST 2020

A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.

The FEBS journal

Sicari D,Delaunay-Moisan A,Combettes L,Chevet E,Igbaria A

Wed Jan 01 00:00:00 EST 2020

Direct Proteomic Mapping of Cysteine Persulfidation.

Antioxidants & redox signaling

Fu L,Liu K,He J,Tian C,Yu X,Yang J

Fri Nov 20 00:00:00 EST 2020

Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazone fragment as potent and selective anticancer agents.

Bioorganic chemistry

Xu C,Zhou W,Dong G,Qiao H,Peng J,Jia P,Li Y,Liu H,Sun K,Zhao W

Tue Dec 01 00:00:00 EST 2020

Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4.

Canadian journal of physiology and pharmacology

Tian Y,Lv W,Lu C,Jiang Y,Yang X,Song M

Thu Oct 01 00:00:00 EDT 2020

Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.

Clinical and experimental immunology

Uzawa A,Mori M,Masuda H,Ohtani R,Uchida T,Aoki R,Kuwabara S

Sun Nov 01 00:00:00 EDT 2020

Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.

British journal of pharmacology

Wei B,Lin Q,Ji YG,Zhao YC,Ding LN,Zhou WJ,Zhang LH,Gao CY,Zhao W

Wed Aug 01 00:00:00 EDT 2018

Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.

British journal of pharmacology

Wei B,Lin Q,Ji YG,Zhao YC,Ding LN,Zhou WJ,Zhang LH,Gao CY,Zhao W

Wed Aug 01 00:00:00 EDT 2018

Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.

Antioxidants & redox signaling

Shi XJ,Ding L,Zhou W,Ji Y,Wang J,Wang H,Ma Y,Jiang G,Tang K,Ke Y,Zhao W,Liu HM

Mon Jul 10 00:00:00 EDT 2017

Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.

Antioxidants & redox signaling

Shi XJ,Ding L,Zhou W,Ji Y,Wang J,Wang H,Ma Y,Jiang G,Tang K,Ke Y,Zhao W,Liu HM

Mon Jul 10 00:00:00 EDT 2017

Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.

Journal of cellular biochemistry

Liu GY,Shi JX,Shi SL,Liu F,Rui G,Li X,Gao LB,Deng XL,Li QF

Fri Dec 01 00:00:00 EST 2017

Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.

Journal of cellular biochemistry

Liu GY,Shi JX,Shi SL,Liu F,Rui G,Li X,Gao LB,Deng XL,Li QF

Fri Dec 01 00:00:00 EST 2017

Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.

Journal of cellular biochemistry

Liu GY,Shi JX,Shi SL,Liu F,Rui G,Li X,Gao LB,Deng XL,Li QF

Fri Dec 01 00:00:00 EST 2017

Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.

Journal of cellular biochemistry

Liu GY,Shi JX,Shi SL,Liu F,Rui G,Li X,Gao LB,Deng XL,Li QF

Fri Dec 01 00:00:00 EST 2017

Quantitative proteomic analysis of a paired human liver healthy versus carcinoma cell lines with the same genetic background to identify potential hepatocellular carcinoma markers.

Proteomics. Clinical applications

Bao H,Song P,Liu Q,Liu Y,Yun D,Saiyin H,Du R,Zhang Y,Fan H,Yang P,Chen X

Mon Jun 01 00:00:00 EDT 2009

Quantitative proteomic analysis of a paired human liver healthy versus carcinoma cell lines with the same genetic background to identify potential hepatocellular carcinoma markers.

Proteomics. Clinical applications

Bao H,Song P,Liu Q,Liu Y,Yun D,Saiyin H,Du R,Zhang Y,Fan H,Yang P,Chen X

Mon Jun 01 00:00:00 EDT 2009

Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue.

Hepatobiliary & pancreatic diseases international : HBPD INT

Chen JH,Ni RZ,Xiao MB,Guo JG,Zhou JW

Wed Apr 01 00:00:00 EDT 2009

Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue.

Hepatobiliary & pancreatic diseases international : HBPD INT

Chen JH,Ni RZ,Xiao MB,Guo JG,Zhou JW

Wed Apr 01 00:00:00 EDT 2009

Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue.

Hepatobiliary & pancreatic diseases international : HBPD INT

Chen JH,Ni RZ,Xiao MB,Guo JG,Zhou JW

Wed Apr 01 00:00:00 EDT 2009

Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue.

Hepatobiliary & pancreatic diseases international : HBPD INT

Chen JH,Ni RZ,Xiao MB,Guo JG,Zhou JW

Wed Apr 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: Antioxidant enzyme AOE372; AOE37-2; EC 1.11.1.15; epididymis secretory sperm binding protein Li 97n; Peroxiredoxin IV; Peroxiredoxin-4; Prx 4; Prx IV; Prx-IV; Thioredoxin dependent peroxide reductase A0372; thioredoxin peroxidase (antioxidant enzyme); Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372; Thioredoxin-dependent peroxiredoxin 4

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Gene Aliases: AOE37-2; AOE372; HEL-S-97n; PRDX4; PRX-4; Prx-iv; Prx4; Rno2CysPrx04; TRANK

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UniProt ID: (Human) Q13162, (Rat) Q9Z0V5, (Mouse) O08807

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Entrez Gene ID: (Human) 10549, (Rat) 85274, (Mouse) 53381

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Function(s)

protein binding thioredoxin peroxidase activity protein homodimerization activity peroxidase activity peroxiredoxin activity antioxidant activity oxidoreductase activity peroxidase

Process(es)

I-kappaB phosphorylation spermatogenesis male gonad development 4-hydroxyproline metabolic process protein maturation by protein folding extracellular matrix organization cell redox homeostasis oxidation-reduction process reactive oxygen species metabolic process cellular oxidant detoxification negative regulation of male germ cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PRDX4 Polyclonal Antibody

PRDX4 Antibody (10703-1-AP) in ICC/IF

Product Details

10703-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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