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Product Details
MA5-32935
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
8A8
Immunogen
Recombinant full length Human PRMT1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2802570
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family. Arginine methylation is an irreversible post translational modification which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Increased expression of PRMT1 may play a role in various types of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; Histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; Interferon receptor 1-bound protein 4; Protein arginine N-methyltransferase 1
Gene Aliases: ANM1; HCP1; HMT2; HRMT1L2; IR1B4; PRMT1
UniProt ID: (Human) Q99873
Entrez Gene ID: (Human) 3276
protein binding
methyltransferase activity
N-methyltransferase activity
protein methyltransferase activity
methyl-CpG binding
protein-arginine N-methyltransferase activity
enzyme binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
identical protein binding
histone methyltransferase activity (H4-R3 specific)
poly(A) RNA binding
mitogen-activated protein kinase p38 binding
protein modifying enzyme
regulation of transcription, DNA-templated
protein methylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell surface receptor signaling pathway
histone methylation
peptidyl-arginine methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
neuron projection development
histone H4-R3 methylation
positive regulation of erythrocyte differentiation
negative regulation of megakaryocyte differentiation
positive regulation of hemoglobin biosynthetic process
positive regulation of p38MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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