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Immunogen sequence: SQLTATQTR TVNKHGDEII TSTTSNYETQ TFSSKTEWRV RAISAANLHL RTNHIYVSSD DIKETGYTYI LPKNVLKKFI CISDLRAQIA GYLYGVSPPD NPQVKEIRCI VMVPQWGTHQ TVHLPGQLPQ HEYLKEMEPL GWIHTQPNES PQLSPQDVTT HAKIMADNPS WDGEKTIIIT CSFTPGSCTL TAYKLTPSGY EWGRQNTDKG NNPKGYLPSH YERVQMLLSD RFLGFFMVPA QSSWNYNFMG VRHDPNMKYE LQLANPKEFY HEVHRPSHFL NFALLQEGEV YSADREDLYA (2037-2335 aa encoded by BC064370)
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 220 kDa U5 snRNP-specific protein; apoptosis-regulated protein 1; apoptosis-regulated protein 2; H PRPC8; p220; Pre-mRNA-processing-splicing factor 8; precursor mRNA processing protein; PRP8 homolog; PRP8 pre-mRNA processing factor 8 homolog; spl; Splicing factor Prp8; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p
Gene Aliases: HPRP8; PRP8; PRPC8; PRPF8; RP13; SNRNP220
UniProt ID: (Human) Q6P2Q9
Entrez Gene ID: (Human) 10594
Molecular Function:
RNA splicing factor
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