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PRPS1 Polyclonal Antibody

PRPS1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 19

PRPS1 Antibody (15549-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using PRPS1 antibody 15549-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

PRPS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRPS1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15549-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRPS1 Fusion Protein Ag7907 (1-318 aa encoded by BC001605)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPNIKIFSG SSHQDLSQKI ADRLGLELGK VVTKKFSNQE TCVEIGESVR GEDVYIVQSG CGEINDNLME LLIMINACKI ASASRVTAVI PCFPYARQDK KDKSRAPISA KLVANMLSVA GADHIITMDL HASQIQGFFD IPVDNLYAEP AVLKWIRENI SEWRNCTIVS PDAGGAKRVT SIADRLNVDF ALIHKERKKA NEVDRMVLVG DVKDRVAILV DDMADTCGTI CHAADKLLSA GATRVYAILT HGIFSGPAIS RINNACFEAV VVTNTIPQED KMKHCSKIQV IDISMILAEA IRRTHNGESV SYLFSHVPL (1-318 aa encoded by BC001605 )

Target Information

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Direct stimulation of de novo nucleotide synthesis by O-GlcNAcylation.

Nature chemical biology

Chen L,Zhou Q,Zhang P,Tan W,Li Y,Xu Z,Ma J,Kupfer GM,Pei Y,Song Q,Pei H

Mon Jan 01 00:00:00 EST 2024

Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation.

Cellular and molecular life sciences : CMLS

Chang CC,Peng M,Zhong J,Zhang Z,Keppeke GD,Sung LY,Liu JL

Thu Jul 14 00:00:00 EDT 2022

NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.

Frontiers in immunology

Xiong G,Feng Y,Yi X,Zhang X,Li X,Yang L,Yi Z,Sai B,Yang Z,Zhang Q,Kuang Y,Zhu Y

Mon Oct 10 00:00:00 EDT 2022

NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.

Frontiers in immunology

Xiong G,Feng Y,Yi X,Zhang X,Li X,Yang L,Yi Z,Sai B,Yang Z,Zhang Q,Kuang Y,Zhu Y

Mon Oct 10 00:00:00 EDT 2022

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.

Nature communications

Yang R,Yang C,Ma L,Zhao Y,Guo Z,Niu J,Chu Q,Ma Y,Li B

Thu Nov 17 00:00:00 EST 2022

Mitochondrial NADP⁺ is essential for proline biosynthesis during cell growth.

Nature metabolism

Tran DH,Kesavan R,Rion H,Soflaee MH,Solmonson A,Bezwada D,Vu HS,Cai F,Phillips JA,DeBerardinis RJ,Hoxhaj G

Thu Apr 01 00:00:00 EDT 2021

Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production.

Frontiers in cell and developmental biology

Chen X,Wu M,Liang N,Lu J,Qu S,Chen H

Wed Apr 21 00:00:00 EDT 2021

Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production.

Frontiers in cell and developmental biology

Chen X,Wu M,Liang N,Lu J,Qu S,Chen H

Wed Apr 21 00:00:00 EDT 2021

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.

Science advances

Srivastava S,Sahu U,Zhou Y,Hogan AK,Sathyan KM,Bodner J,Huang J,Wong KA,Khalatyan N,Savas JN,Ntziachristos P,Ben-Sahra I,Foltz DR

Fri Jan 01 00:00:00 EST 2021

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.

Science advances

Srivastava S,Sahu U,Zhou Y,Hogan AK,Sathyan KM,Bodner J,Huang J,Wong KA,Khalatyan N,Savas JN,Ntziachristos P,Ben-Sahra I,Foltz DR

Fri Jan 01 00:00:00 EST 2021

Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.

The Journal of investigative dermatology

Gu Z,Zhang H,Guo X,Cao Y

Sat Aug 01 00:00:00 EDT 2020

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Oncotarget

Gu Z,Zhang H,Li Y,Shen S,Yin X,Zhang W,Cheng R,Zhang Y,Zhang X,Chen H,Huang B,Cao Y

Tue Dec 26 00:00:00 EST 2017

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Oncotarget

Gu Z,Zhang H,Li Y,Shen S,Yin X,Zhang W,Cheng R,Zhang Y,Zhang X,Chen H,Huang B,Cao Y

Tue Dec 26 00:00:00 EST 2017

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Science (New York, N.Y.)

Ben-Sahra I,Hoxhaj G,Ricoult SJH,Asara JM,Manning BD

Fri Feb 12 00:00:00 EST 2016

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Science (New York, N.Y.)

Ben-Sahra I,Hoxhaj G,Ricoult SJH,Asara JM,Manning BD

Fri Feb 12 00:00:00 EST 2016

Quantitative proteomic dissection of a native 14-3-3ε interacting protein complex associated with hepatocellular carcinoma.

Amino acids

Bai C,Tang S,Bai C,Chen X

Tue Apr 01 00:00:00 EDT 2014

Quantitative proteomic dissection of a native 14-3-3ε interacting protein complex associated with hepatocellular carcinoma.

Amino acids

Bai C,Tang S,Bai C,Chen X

Tue Apr 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: deafness 2, perceptive, congenital; deafness, X-linked 2, perceptive, congenital; dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1); Phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; PPRibP; PRS-I; ribose-phosphate diphosphokinase 1; Ribose-phosphate pyrophosphokinase 1

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Gene Aliases: 2310010D17Rik; ARTS; C76571; C76678; CMTX5; DFN2; DFNX1; PPRibP; Prps-1; PRPS1; PRS-I; PRSI

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UniProt ID: (Human) P60891, (Mouse) Q9D7G0, (Rat) P60892

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Entrez Gene ID: (Human) 5631, (Mouse) 19139, (Rat) 29562

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Function(s)

magnesium ion binding ribose phosphate diphosphokinase activity protein binding ATP binding AMP binding kinase activity GDP binding carbohydrate binding protein homodimerization activity ADP binding nucleotide binding transferase activity metal ion binding nucleotide kinase

Process(es)

5-phosphoribose 1-diphosphate biosynthetic process purine nucleobase metabolic process purine nucleotide biosynthetic process AMP biosynthetic process pyrimidine nucleotide biosynthetic process nervous system development phosphorylation organ regeneration urate biosynthetic process hypoxanthine biosynthetic process ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process ribose phosphate metabolic process cellular biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PRPS1 Polyclonal Antibody

PRPS1 Antibody (15549-1-AP) in ICC/IF

Product Details

15549-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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