Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: RLSPWGLAP LFRSVRSKLE SFADIFLTPN KTPQPPPPSP PMKLELKIAI SEAEQSGAAE GTASVSPRPP IRQWRTQDHN TPALLPKPSL GRSYSCPDLG PPGPGTCTWP PAPPQPSRPR PRRHTVGGGE MARAPPPPRP CLRKEVFPLG GVGASPSLTT SCSSTASTSF SEPAEPRLGS TKGKEPRASK DQVLSEPETK TMGKVSRFRI RRTPARPQLN LTPMGLPRPI RLNKKEFSLE EIYTNKNYQS PTTRRTFETI FEEPRERNGT LIFTSSRKLR RAVEFRDSSL PRSRRPSRGV RAAGGRTVPP NVAPSPDVGP LLQQRLEELD ALLLEEETVD REQPHWT (240-585 aa encoded by BC000119 )
The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene.
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Protein Aliases: Proline-rich protein 14
Gene Aliases: BC006909; PRR14
UniProt ID: (Human) Q9BWN1, (Mouse) Q7TPN9
Entrez Gene ID: (Human) 78994, (Mouse) 233895
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