Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%
This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: proline rich Gla (G-carboxyglutamic acid) 1; Proline-rich gamma-carboxyglutamic acid protein 1; proline-rich Gla (G-carboxyglutamic acid) polypeptide 1; Proline-rich Gla protein 1; Transmembrane gamma-carboxyglutamic acid protein 1
Gene Aliases: PRGP1; PRRG1; TMG1
UniProt ID: (Human) O14668
Entrez Gene ID: (Human) 5638
Molecular Function:
serine protease
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