Product References
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma.
The Journal of clinical investigation
D'Avola A,Legrave N,Tajan M,Chakravarty P,Shearer RL,King HW,Kluckova K,Cheung EC,Clear AJ,Gunawan AS,Zhang L,James LK,MacRae JI,Gribben JG,Calado DP,Vousden KH,Riches JC
Published figure using PSAT1 polyclonal antibody (Product # PA5-22124) in Western Blot
Mon May 02 00:00:00 EDT 2022
Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors.
Cell reports
Choi BH,Rawat V,Högström J,Burns PA,Conger KO,Ozgurses ME,Patel JM,Mehta TS,Warren A,Selfors LM,Muranen T,Coloff JL
PA5-22124 was used in Western Blot to analyze lineage-dependent gene expression in human breast tumors to identify differences in metabolic gene expression that may limit pathway redundancy and create therapeutic vulnerabilities.
Tue Jan 18 00:00:00 EST 2022
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.
The Journal of clinical investigation
Zhang Y,Yu H,Zhang J,Gao H,Wang S,Li S,Wei P,Liang J,Yu G,Wang X,Li X,Li D,Yang W
PA5-22124 was used in Western Blot to reveal a potentially new role and mechanism of SAM-promoted tumor metastasis but also demonstrate a regulatory mechanism of PHGDH activity by monoubiquitination.
Mon Nov 01 00:00:00 EDT 2021
Targeting phosphoglycerate dehydrogenase in multiple myeloma.
Experimental hematology & oncology
Elsaadi S,Steiro I,Abdollahi P,Vandsemb EN,Yang R,Slørdahl TS,Rø TB,Menu E,Sponaas AM,Børset M
Published figure using PSAT1 polyclonal antibody (Product # PA5-22124) in Western Blot
Mon Jan 04 00:00:00 EST 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
PA5-22124 was used in Immunohistochemistry to show that inhibition of PHGDH, the first step in the SSP, cooperates with serine and glycine depletion to inhibit one-carbon metabolism and cancer growth.
Thu Jan 14 00:00:00 EST 2021
Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells.
Cancers
Białopiotrowicz E,Noyszewska-Kania M,Kachamakova-Trojanowska N,Łoboda A,Cybulska M,Grochowska A,Kopczyński M,Mikula M,Prochorec-Sobieszek M,Firczuk M,Graczyk-Jarzynka A,Zagożdżon R,Ząbek A,Młynarz P,Dulak J,Górniak P,Szydłowski M,Pyziak K,Martyka J,Sroka-Porada A,Jabłońska E,Polak A,Kowalczyk P,Szumera-Ciećkiewicz A,Chapuy B,Rzymski T,Brzózka K,Juszczyński P
Published figure using PSAT1 polyclonal antibody (Product # PA5-22124) in Immunohistochemistry
Tue Mar 03 00:00:00 EST 2020
Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells.
Cancers
Białopiotrowicz E,Noyszewska-Kania M,Kachamakova-Trojanowska N,Łoboda A,Cybulska M,Grochowska A,Kopczyński M,Mikula M,Prochorec-Sobieszek M,Firczuk M,Graczyk-Jarzynka A,Zagożdżon R,Ząbek A,Młynarz P,Dulak J,Górniak P,Szydłowski M,Pyziak K,Martyka J,Sroka-Porada A,Jabłońska E,Polak A,Kowalczyk P,Szumera-Ciećkiewicz A,Chapuy B,Rzymski T,Brzózka K,Juszczyński P
Published figure using PSAT1 polyclonal antibody (Product # PA5-22124) in Immunohistochemistry
Tue Mar 03 00:00:00 EST 2020
Translational reprogramming marks adaptation to asparagine restriction in cancer.
Nature cell biology
Pathria G,Lee JS,Hasnis E,Tandoc K,Scott DA,Verma S,Feng Y,Larue L,Sahu AD,Topisirovic I,Ruppin E,Ronai ZA
PA5-22124 was used in Western Blotting to demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells.
Sun Dec 01 00:00:00 EST 2019
Nf1 loss promotes Kras-driven lung adenocarcinoma and results in Psat1-mediated glutamate dependence.
EMBO molecular medicine
Wang X,Min S,Liu H,Wu N,Liu X,Wang T,Li W,Shen Y,Wang H,Qian Z,Xu H,Zhao C,Chen Y
PA5-22124 was used in Western Blotting to evaluate the impact of Nf1 loss on lung adenocarcinoma development using a CRISPR/Cas9 platform in a murine model of Kras-mutant lung adenocarcinoma.
Sat Jun 01 00:00:00 EDT 2019
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.
Science signaling
Selvarajah B,Azuelos I,Platé M,Guillotin D,Forty EJ,Contento G,Woodcock HV,Redding M,Taylor A,Brunori G,Durrenberger PF,Ronzoni R,Blanchard AD,Mercer PF,Anastasiou D,Chambers RC
PA5-22124 was used in Western Blotting to show that TGF-β1-induced ATF4 production dependes on cooperation between canonical TGF-β1 signaling through Smad3 and activation of mechanistic target of mTORC1and its downstream target eukaryotic translation initiation factor 4E-BP1.
Tue May 21 00:00:00 EDT 2019
Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets.
Oncotarget
Lodovichi S,Mercatanti A,Cervelli T,Galli A
PA5-22124 was used in Western Blotting to identify candidate genes that could have an effect on PARP inhibition therapy.
Fri Apr 12 00:00:00 EDT 2019
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
Cell reports
Meléndez-Rodríguez F,Urrutia AA,Lorendeau D,Rinaldi G,Roche O,Böğürcü-Seidel N,Ortega Muelas M,Mesa-Ciller C,Turiel G,Bouthelier A,Hernansanz-Agustín P,Elorza A,Escasany E,Li QOY,Torres-Capelli M,Tello D,Fuertes E,Fraga E,Martínez-Ruiz A,Pérez B,Giménez-Bachs JM,Salinas-Sánchez AS,Acker T,Sánchez Prieto R,Fendt SM,De Bock K,Aragonés J
PA5-22124 was used in Western Blotting to characterise the signalling pathways that rewire aspartate biosynthesis to control cell growth.
Tue Feb 26 00:00:00 EST 2019
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
The Journal of pathology
Svoboda LK,Teh SSK,Sud S,Kerk S,Zebolsky A,Treichel S,Thomas D,Halbrook CJ,Lee HJ,Kremer D,Zhang L,Klossowski S,Bankhead AR,Magnuson B,Ljungman M,Cierpicki T,Grembecka J,Lyssiotis CA,Lawlor ER
PA5-22124 was used in Western Blotting to study the mechanistic basis of menin-MLL-mediated oncogenic activity in Ewing sarcoma.
Sun Jul 01 00:00:00 EDT 2018
Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ishida CT,Zhang Y,Bianchetti E,Shu C,Nguyen TTT,Kleiner G,Sanchez-Quintero MJ,Quinzii CM,Westhoff MA,Karpel-Massler G,Prabhu VV,Allen JE,Siegelin MD
PA5-22124 was used in Simple Western - Size to suggest that c-myc expression predicts therapeutic responses to imipridones and that imipridones lead to suppression of tumor cell energy metabolism, eliciting unique metabolic vulnerabilities that can be exploited for clinical relevant drug combination therapies.
Thu Nov 01 00:00:00 EDT 2018
Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation.
Molecular cancer
Bellissimo T,Ganci F,Gallo E,Sacconi A,Tito C,De Angelis L,Pulito C,Masciarelli S,Diso D,Anile M,Petrozza V,Giangaspero F,Pescarmona E,Facciolo F,Venuta F,Marino M,Blandino G,Fazi F
Published figure using PSAT1 polyclonal antibody (Product # PA5-22124) in Immunohistochemistry
Wed May 10 00:00:00 EDT 2017
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Nature genetics
DeNicola GM,Chen PH,Mullarky E,Sudderth JA,Hu Z,Wu D,Tang H,Xie Y,Asara JM,Huffman KE,Wistuba II,Minna JD,DeBerardinis RJ,Cantley LC
PA5-22124 was used in western blot to characterize serine biosynthesis and NRF2 regulation in non-small cell lung cancer
Tue Dec 01 00:00:00 EST 2015
Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth.
Oncotarget
Chen J,Chung F,Yang G,Pu M,Gao H,Jiang W,Yin H,Capka V,Kasibhatla S,Laffitte B,Jaeger S,Pagliarini R,Chen Y,Zhou W
PA5-22124 was used in western blot to learn how breast tumor maintenance and growth requires phosphogylcerate dehydrogenase
Sun Dec 01 00:00:00 EST 2013
