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PSCA (Prostate Stem Cell antigen) is a cell surface antigen, which is overexpressed in approximately40% of primary prostate cancers and in as many as 100% of metastatic ones. PSCA is also overexpressed in a majority of transitional cell and pancreatic carcinomas. Antibody directed against PSCA inhibits tumorigenesis, slows tumor growth, prolongs survival and prevents metastasis in a preclinical zenograft model indicating that PSCA may have utility as a prognostic marker and/or therapeutic target in prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: caldesmon; H-CAD; HCAD; L-CAD; NAG22; Prostate stem cell antigen; UNQ206
Gene Aliases: 2210408B04Rik; PRO232; PSCA; UNQ206/PRO232
UniProt ID: (Human) O43653, (Mouse) P57096
Entrez Gene ID: (Human) 8000, (Mouse) 72373
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