Proteintech

PSD95 Recombinant Rabbit Monoclonal Antibody (1I22)

View all (41) PSD-95 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

81106-1-RR100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:50,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

proprietary

Class

Recombinant Monoclonal

Type

Antibody

Clone

1I22

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: discs large homolog 4; Disks large homolog 4; FLJ97752; FLJ98574; post synaptic density; post-synaptic density protein 95; Postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SAP-90; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15

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Gene Aliases: DLG4; Dlgh4; PSD-95; PSD95; SAP-90; SAP90; SAP90A

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UniProt ID: (Human) P78352, (Rat) P31016, (Mouse) Q5NCV6

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Entrez Gene ID: (Human) 1742, (Rat) 29495, (Mouse) 13385

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Function(s)
guanylate kinase activity Ras guanyl-nucleotide exchange factor activity protein binding protein C-terminus binding ligand-gated ion channel activity kinase binding protein phosphatase binding PDZ domain binding beta-1 adrenergic receptor binding D1 dopamine receptor binding P2Y1 nucleotide receptor binding protein complex binding acetylcholine receptor binding ionotropic glutamate receptor binding neuroligin family protein binding scaffold protein binding receptor binding protein kinase binding glutamate receptor binding structural molecule activity neurexin family protein binding scaffold/adaptor protein
Process(es)
MAPK cascade negative regulation of receptor internalization protein complex assembly signal transduction positive regulation of cytosolic calcium ion concentration chemical synaptic transmission nervous system development learning synaptic vesicle maturation ion transmembrane transport social behavior protein localization to synapse locomotory exploration behavior positive regulation of GTPase activity establishment of protein localization establishment or maintenance of epithelial cell apical/basal polarity GMP metabolic process GDP metabolic process regulation of long-term neuronal synaptic plasticity positive regulation of synaptic transmission neuromuscular process controlling balance dendritic spine morphogenesis vocalization behavior AMPA glutamate receptor clustering receptor localization to synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential regulation of grooming behavior neuronal ion channel clustering nucleotide phosphorylation locomotory behavior response to cocaine regulation of neuronal synaptic plasticity
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