QED Bioscience

PSD95 Monoclonal Antibody (7E3-1B8)

View all (41) PSD-95 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

56457-100UG

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunocytochemistry (ICC/IF)

1-10 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

7E3-1B8

Immunogen

Recombinant rat PSD95

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: discs large homolog 4; Disks large homolog 4; FLJ97752; FLJ98574; post synaptic density; Postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SAP-90; Synapse-associated protein 90; synapse-associated protein SAP90

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Gene Aliases: Dlg4; Dlgh4; PSD-95; PSD95; SAP90; SAP90A

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UniProt ID: (Rat) P31016, (Mouse) Q5NCV6

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Entrez Gene ID: (Bovine) 100137840, (Rat) 29495, (Mouse) 13385

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Function(s)
guanylate kinase activity receptor binding protein binding protein C-terminus binding protein kinase binding protein phosphatase binding PDZ domain binding beta-1 adrenergic receptor binding D1 dopamine receptor binding P2Y1 nucleotide receptor binding protein complex binding acetylcholine receptor binding glutamate receptor binding ionotropic glutamate receptor binding scaffold protein binding structural molecule activity kinase binding neurexin family protein binding neuroligin family protein binding scaffold/adaptor protein
Process(es)
negative regulation of receptor internalization protein complex assembly positive regulation of cytosolic calcium ion concentration synaptic vesicle maturation social behavior protein localization to synapse locomotory exploration behavior neuronal ion channel clustering establishment of protein localization establishment or maintenance of epithelial cell apical/basal polarity nucleotide phosphorylation regulation of long-term neuronal synaptic plasticity positive regulation of synaptic transmission neuromuscular process controlling balance dendritic spine morphogenesis vocalization behavior AMPA glutamate receptor clustering receptor localization to synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential regulation of grooming behavior signal transduction chemical synaptic transmission nervous system development locomotory behavior response to cocaine regulation of neuronal synaptic plasticity
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