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Product Details
PA5-96774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 267-384 of human PSEN2 (NP_0004382)
Conjugate
Form
Liquid
Concentration
2.65 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808576
Product Specific Information
Positive Samples: A-549, Human placenta, HepG2, HeLa, Mouse liver, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein
Immunogen sequence: VLCPKGPLRM LVETAQERNE PIFPALIYSS AMVWTVGMAK LDPSSQGALQ LPYDPEMEED SYDSFGEPSY PEVFEPPLTG YPGEELEEEE ERGVKLGLGD FIFYSVLVGK AAATGSGD
Target Information
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; PS-2; PSEN 2; STM-2
Gene Aliases: AD3L; AD4; Ad4h; ALG-3; Alg3; CMD1V; PS-2; PS2; PSEN2; PSNL2; STM2
UniProt ID: (Human) P49810, (Rat) O88777, (Mouse) Q61144
Entrez Gene ID: (Human) 5664, (Rat) 81751, (Mouse) 19165
response to hypoxia
membrane protein ectodomain proteolysis
calcium ion transport
Notch signaling pathway
Notch receptor processing
protein processing
membrane protein intracellular domain proteolysis
intracellular signal transduction
amyloid precursor protein catabolic process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of catalytic activity
ephrin receptor signaling pathway
beta-amyloid metabolic process
negative regulation of transcription from RNA polymerase II promoter
cell fate specification
somitogenesis
positive regulation of receptor recycling
negative regulation of protein phosphorylation
hair follicle development
hematopoietic progenitor cell differentiation
T cell activation involved in immune response
myeloid leukocyte differentiation
proteolysis
negative regulation of epidermal growth factor-activated receptor activity
regulation of epidermal growth factor-activated receptor activity
learning or memory
memory
protein transport
dorsal/ventral neural tube patterning
embryonic limb morphogenesis
forebrain development
negative regulation of protein complex assembly
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
endoplasmic reticulum calcium ion homeostasis
locomotion
regulation of protein binding
skin morphogenesis
cellular protein metabolic process
regulation of synaptic plasticity
lung alveolus development
thymus development
brain morphogenesis
positive regulation of coagulation
T cell receptor signaling pathway
negative regulation of ubiquitin-protein transferase activity
protein maturation
cardiac muscle contraction
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic signaling pathway
embryo development
anagen
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