Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MADGGSERA DGRIVKMEVD YSATVDQRLP ECAKLAKEGR LQEVIETLLS LEKQTRTASD MVSTSRILVA VVKMCYEAKE WDLLNENIML LSKRRSQLKQ AVAKMVQQCC TYVEEITDLP IKLRLIDTLR MVTEGKIYVE IERARLTKTL ATIKEQNGDV KEAASILQEL QVETYGSMEK KERVEFILEQ MRLCLAVKDY IRTQIISKKI NTKFFQEENT EKLKLKYYNL MIQLDQHEGS YLSICKHYRA IYDTPCIQAE SEKWQQALKS VVLYVILAPF DNEQSDLVHR ISGDKKLEEI PKYKDLLKLF TTMELMRWST L (1-320 aa encoded by BC019062)
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; proteasome 26S non-ATPase subunit 12; proteasome 26S subunit non-ATPase 12
Gene Aliases: 1500002F15Rik; AI480719; P55; PSMD12; Rpn5
UniProt ID: (Human) O00232, (Mouse) Q9D8W5
Entrez Gene ID: (Human) 5718, (Mouse) 66997, (Rat) 287772
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