Product References
Hyperphosphorylated PTEN exerts oncogenic properties.
Nature communications
van Ree JH,Jeganathan KB,Fierro Velasco RO,Zhang C,Can I,Hamada M,Li H,Baker DJ,van Deursen JM
51-2400 was used in Western Blotting to suggest that C-tail hyperphosphorylation creates oncogenic PTEN and is a potential target for anti-cancer therapy.
Wed May 24 00:00:00 EDT 2023
Hyperphosphorylated PTEN exerts oncogenic properties.
Nature communications
van Ree JH,Jeganathan KB,Fierro Velasco RO,Zhang C,Can I,Hamada M,Li H,Baker DJ,van Deursen JM
51-2400 was used in Western Blotting to suggest that C-tail hyperphosphorylation creates oncogenic PTEN and is a potential target for anti-cancer therapy.
Wed May 24 00:00:00 EDT 2023
Hyperphosphorylated PTEN exerts oncogenic properties.
Nature communications
van Ree JH,Jeganathan KB,Fierro Velasco RO,Zhang C,Can I,Hamada M,Li H,Baker DJ,van Deursen JM
51-2400 was used in Western Blotting to suggest that C-tail hyperphosphorylation creates oncogenic PTEN and is a potential target for anti-cancer therapy.
Wed May 24 00:00:00 EDT 2023
Hyperphosphorylated PTEN exerts oncogenic properties.
Nature communications
van Ree JH,Jeganathan KB,Fierro Velasco RO,Zhang C,Can I,Hamada M,Li H,Baker DJ,van Deursen JM
51-2400 was used in Western Blotting to suggest that C-tail hyperphosphorylation creates oncogenic PTEN and is a potential target for anti-cancer therapy.
Wed May 24 00:00:00 EDT 2023
The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem Glioma.
Cancers
Stewart CE,Guerra-García ME,Luo L,Williams NT,Ma Y,Regal JA,Ghosh D,Sansone P,Oldham M,Deland K,Becher OJ,Kirsch DG,Reitman ZJ
51-2400 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that deletion of Atm in the tumor cells does not extend survival of mice bearing Pten-null brainstem gliomas after focal brain irradiation.
Sat Sep 17 00:00:00 EDT 2022
The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem Glioma.
Cancers
Stewart CE,Guerra-García ME,Luo L,Williams NT,Ma Y,Regal JA,Ghosh D,Sansone P,Oldham M,Deland K,Becher OJ,Kirsch DG,Reitman ZJ
51-2400 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that deletion of Atm in the tumor cells does not extend survival of mice bearing Pten-null brainstem gliomas after focal brain irradiation.
Sat Sep 17 00:00:00 EDT 2022
The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.
Cells
Garrido JAMG,Alcantara KMM,Danac JMC,Serrano FEC,Cutiongco-de la Paz EM,Garcia RL
Published figure using PTEN polyclonal antibody (Product # 51-2400) in Western Blot
Sun Dec 05 00:00:00 EST 2021
Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer.
Life (Basel, Switzerland)
Prvanović M,Nedeljković M,Tanić N,Tomić T,Terzić T,Milovanović Z,Maksimović Z,Tanić N
51-2400 was used in Immunohistochemistry to investigate the PI3K/PTEN/Akt/mTOR pathway as one of the most frequently deregulated pathways in cancer.
Wed Nov 17 00:00:00 EST 2021
Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer.
Life (Basel, Switzerland)
Prvanović M,Nedeljković M,Tanić N,Tomić T,Terzić T,Milovanović Z,Maksimović Z,Tanić N
51-2400 was used in Immunohistochemistry to investigate the PI3K/PTEN/Akt/mTOR pathway as one of the most frequently deregulated pathways in cancer.
Wed Nov 17 00:00:00 EST 2021
Melatonin ameliorates renal fibroblast-myofibroblast transdifferentiation and renal fibrosis through miR-21-5p regulation.
Journal of cellular and molecular medicine
Li N,Wang Z,Gao F,Lei Y,Li Z
Published figure using PTEN polyclonal antibody (Product # 51-2400) in Western Blot
Fri May 01 00:00:00 EDT 2020
EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.
International journal of clinical and experimental pathology
Tsubochi H,Minegishi K,Goto A,Nakamura R,Matsubara D,Dobashi Y
51-2400 was used in Immunohistochemistry to show that EphA2 may be a target of miR-200a in AC and in pStage I/II cancers that exhibit AKT2 CNI.
Wed Sep 16 00:00:00 EDT 2020
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.
Nature genetics
Chen J,Guccini I,Di Mitri D,Brina D,Revandkar A,Sarti M,Pasquini E,Alajati A,Pinton S,Losa M,Civenni G,Catapano CV,Sgrignani J,Cavalli A,D'Antuono R,Asara JM,Morandi A,Chiarugi P,Crotti S,Agostini M,Montopoli M,Masgras I,Rasola A,Garcia-Escudero R,Delaleu N,Rinaldi A,Bertoni F,Bono J,Carracedo A,Alimonti A
51-2400 was used in Immunohistochemistry on paraffin embedded tissues to study the mechanisms by which mitochondrial metabolism supports cancer anabolism.
Thu Feb 01 00:00:00 EST 2018
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Nature
Zabala-Letona A,Arruabarrena-Aristorena A,Martín-Martín N,Fernandez-Ruiz S,Sutherland JD,Clasquin M,Tomas-Cortazar J,Jimenez J,Torres I,Quang P,Ximenez-Embun P,Bago R,Ugalde-Olano A,Loizaga-Iriarte A,Lacasa-Viscasillas I,Unda M,Torrano V,Cabrera D,van Liempd SM,Cendon Y,Castro E,Murray S,Revandkar A,Alimonti A,Zhang Y,Barnett A,Lein G,Pirman D,Cortazar AR,Arreal L,Prudkin L,Astobiza I,Valcarcel-Jimenez L,Zuñiga-García P,Fernandez-Dominguez I,Piva M,Caro-Maldonado A,Sánchez-Mosquera P,Castillo-Martín M,Serra V,Beraza N,Gentilella A,Thomas G,Azkargorta M,Elortza F,Farràs R,Olmos D,Efeyan A,Anguita J,Muñoz J,Falcón-Pérez JM,Barrio R,Macarulla T,Mato JM,Martinez-Chantar ML,Cordon-Cardo C,Aransay AM,Marks K,Baselga J,Tabernero J,Nuciforo P,Manning BD,Marjon K,Carracedo A
51-2400 was used in Immunohistochemistry to show that mechanistic target of rapamycin complex 1 regulates polyamine dynamics, a metabolic route that is essential for oncogenicity.
Thu Jul 06 00:00:00 EDT 2017
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence.
Nature communications
Revandkar A,Perciato ML,Toso A,Alajati A,Chen J,Gerber H,Dimitrov M,Rinaldi A,Delaleu N,Pasquini E,D'Antuono R,Pinton S,Losa M,Gnetti L,Arribas A,Fraering P,Bertoni F,Nepveu A,Alimonti A
512400 was used in immunohistochemistry - paraffin section to demonstrate that PTEN loss results in ADAM17 and NOTCH signaling in prostate cancer cells
Mon Dec 12 00:00:00 EST 2016
Immunopathologic Assessment of PTEN Expression.
Methods in molecular biology (Clifton, N.J.)
Castillo-Martin M,Thin TH,Collazo Lorduy A,Cordon-Cardo C
51-2400 was used in immunohistochemistry - paraffin section to assess PTEN expression by immunopathology
Tue Dec 13 00:00:00 EST 2016
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Cell reports
Toso A,Revandkar A,Di Mitri D,Guccini I,Proietti M,Sarti M,Pinton S,Zhang J,Kalathur M,Civenni G,Jarrossay D,Montani E,Marini C,Garcia-Escudero R,Scanziani E,Grassi F,Pandolfi PP,Catapano CV,Alimonti A
51-2400 was used in Immunohistochemistry on paraffin embedded tissues to demonstrate that immune surveillance of senescent tumour cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments.
Thu Oct 09 00:00:00 EDT 2014
Protein expression of PTEN, insulin-like growth factor I receptor (IGF-IR), and lethal prostate cancer: a prospective study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Zu K,Martin NE,Fiorentino M,Flavin R,Lis RT,Sinnott JA,Finn S,Penney KL,Ma J,Fazli L,Gleave ME,Bismar TA,Stampfer MJ,Pollak MN,Loda M,Mucci LA,Giovannucci E
Fri Nov 01 00:00:00 EDT 2013
PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lotan TL,Gurel B,Sutcliffe S,Esopi D,Liu W,Xu J,Hicks JL,Park BH,Humphreys E,Partin AW,Han M,Netto GJ,Isaacs WB,De Marzo AM
Published figure using PTEN polyclonal antibody (Product # 51-2400) in Immunohistochemistry
Sat Oct 15 00:00:00 EDT 2011
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
Science signaling
Poliseno L,Salmena L,Riccardi L,Fornari A,Song MS,Hobbs RM,Sportoletti P,Varmeh S,Egia A,Fedele G,Rameh L,Loda M,Pandolfi PP
51-2400 was used in Immunohistochemistry to uncover a proto-oncogenic microRNA-dependent network for phosphatase and tensin homologue deleted on chromosome 10 regulation and defined the MCM7 locus as critical in initiating prostate tumourigenesis.
Tue Apr 13 00:00:00 EDT 2010
Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway.
Cancer research
Jimenez AI,Fernandez P,Dominguez O,Dopazo A,Sanchez-Cespedes M
Sat Mar 15 00:00:00 EST 2003
Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation.
Clinical cancer research : an official journal of the American Association for Cancer Research
Soria JC,Lee HY,Lee JI,Wang L,Issa JP,Kemp BL,Liu DD,Kurie JM,Mao L,Khuri FR
Wed May 01 00:00:00 EDT 2002