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Product Details
PA1-46022
Product Specifications
Species Reactivity
Bovine,
Horse,
Cat,
Fish,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to a region within residues 25-100 of the human PTGDS protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2174502
Product Specific Information
This antibody has an 87% sequence homology with ovine and a 82% homology with rabbit.
Suggested positive control: antigen standard for PTGDS (transient overexpression lysate), human brain protein.
Target Information
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; L-PGDS; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; Prostaglandin D synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; testis tissue sperm-binding protein Li 63n
Gene Aliases: 21kDa; L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2; PH2DISO; PTGDS; Ptgs3
UniProt ID: (Cat) Q29487, (Human) P41222, (Bovine) O02853, (Horse) O97921, (Pig) Q29095, (Mouse) O09114, (Rat) P22057
Entrez Gene ID: (Cat) 493852, (Human) 5730, (Bovine) 286858, (Horse) 100067921, (Pig) 397456, (Mouse) 19215, (Rat) 25526
prostaglandin biosynthetic process
transport
cyclooxygenase pathway
regulation of circadian sleep/wake cycle, sleep
response to glucocorticoid
negative regulation of male germ cell proliferation
negative regulation by host of viral process
negative regulation of viral genome replication
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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