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Product Details
PA5-85106
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PTHLH.
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792254
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (85%), Rat (87%), Dog (92%), Pig (91%), Rabbit (87%), Rhesus Monkey (99%), Bovine (91%).
Positive Control: A549, HepG2, HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: osteostatin; parathyroid hormone related peptide; parathyroid hormone-like hormone preproprotein; Parathyroid hormone-like protein; parathyroid hormone-like related protein; Parathyroid hormone-related protein; PLP; PTH-related protein; PTH-rP
Gene Aliases: BDE2; HHM; PLP; PTHLH; PTHR; PTHRP
UniProt ID: (Human) P12272
Entrez Gene ID: (Human) 5744
skeletal system development
osteoblast development
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
epidermis development
regulation of gene expression
positive regulation of cAMP biosynthetic process
negative regulation of chondrocyte differentiation
cAMP metabolic process
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