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Product Details
MA5-41657
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
C5
Immunogen
Recombinant protein Parathyroid Hormone Related Protein. The antigen corresponds to amino acid range 37-177 of the target protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899139
Target Information
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: parathyroid hormone related peptide; parathyroid hormone-like peptide; Parathyroid hormone-like protein; Parathyroid hormone-related protein; parathyroid-like peptide; PLP; PTH-rP; PTHrP
Gene Aliases: PLP; Pthlh; Pthrp
UniProt ID: (Rat) P13085
Entrez Gene ID: (Rat) 24695
skeletal system development
endochondral ossification
osteoblast development
adenylate cyclase-activating G-protein coupled receptor signaling pathway
endoderm development
positive regulation of cell proliferation
regulation of gene expression
protein processing
bone mineralization
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
regulation of chondrocyte differentiation
negative regulation of chondrocyte differentiation
surfactant homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
lung alveolus development
mammary gland bud elongation
nipple sheath formation
Performance Guarantee
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