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Product Details
MA5-50875
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
D1
Immunogen
Recombinant Rat PTHrP protein, Ala37-His177 (Accession #P13085)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3093457
Target Information
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: osteostatin; parathyroid hormone related peptide; parathyroid hormone-like hormone preproprotein; parathyroid hormone-like peptide; Parathyroid hormone-like protein; parathyroid hormone-like related protein; Parathyroid hormone-related protein; parathyroid-like peptide; PLP; PTH-related protein; PTH-rP; PTHrP
Gene Aliases: BDE2; HHM; PLP; PTHLH; PTHR; PTHRP
UniProt ID: (Human) P12272, (Rat) P13085
Entrez Gene ID: (Human) 5744, (Rat) 24695
skeletal system development
osteoblast development
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
epidermis development
regulation of gene expression
positive regulation of cAMP biosynthetic process
negative regulation of chondrocyte differentiation
cAMP metabolic process
endochondral ossification
endoderm development
protein processing
bone mineralization
epithelial cell differentiation
regulation of chondrocyte differentiation
surfactant homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
lung alveolus development
mammary gland bud elongation
nipple sheath formation
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