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FIGURE: 1 / 5
Positive test controls include: MCF7, Mouse skeletal muscle, Mouse brain, Mouse kidney, Mouse liver, Rat brain. The target is usually found in the following locations: Cell membrane, Cytoplasm, Early endosome.
Immunogen sequence: FTEELKKYGV TTLVRVCDAT YDKAPVEKEG IHVLDWPFDD GAPPPNQIVD DWLNLLKTKF REEPGCCVAV H
PRL-2, also known as Protein tyrosine phosphatase 4a2 (Ptp4a2) is a unique nuclear protein tyrosine phosphatase (PTP) that plays a central role in regulating diverse cellular processes. PRL-1 is induced in mitogen-stimulated cells and regenerating liver. PRL-2 exhibits 87% identity to PRL-1 in their amino acid sequences. All mouse PRL proteins contain a C-terminal consensus sequence for prenylation. All PRL proteins bear significant sequence homology to Cdc14p and the tumor suppressor PTEN/MMAC1. PRL-2 is preferentially expressed in skeletal muscle. PRL-2 is also expressed at lower levels in other tissues.
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Protein Aliases: HU-PP-1; OV-1; phosphatase of regenerating liver 2; PRL-2; protein tyrosine phosphatase 4a2; protein tyrosine phosphatase IVA; protein tyrosine phosphatase IVA2; Protein tyrosine phosphatase type IVA 2; Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PTP(CAAXII); tyrosine-phosphatase
Gene Aliases: BM-008; HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2; ptp-IV1a; ptp-IV1b; PTP4A; PTP4A2; PTPCAAX2
UniProt ID: (Human) Q12974, (Rat) Q6P9X4, (Mouse) O70274
Entrez Gene ID: (Human) 8073, (Rat) 85237, (Mouse) 19244
Molecular Function:
protein phosphatase
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